Derivatives of Alpha2-Adrenergic Receptor Agonist

Compound of formula (I) and pharmaceutically acceptable salts or stereoisomers thereof,

• A-X1—Y—ONO2 (I)
• wherein:
• A is selected from
• X1 has the following meanings:
• —C(O)—, —C(O)O—,
• Y is a bivalent radical having the following meanings:
• a)
• straight or branched C1-C20 alkylene, preferably C1-C10, being optionally substituted with one or more of the substituents selected from the group consisting of:
• halogen atoms, hydroxy, -0NO2 or T0, wherein T0 is
• —OC(O)(C1-C10 alkyl)-ONO2 or —O(C1-C10 alkyl)-ONO2;
• cycloalkylene with 5 to 7 carbon atoms into cycloalkylene ring, the ring being optionally substituted with side chains T, wherein T is straight or branched alkyl with from 1 to 10 carbon atoms;
• b)
• c)
• where n is an integer from 0 to 20,
• n1 is an integer from 1 to 20;
• d)
• wherein:
• n1 is as defined above and n2 is an integer from 0 to 2;
• X2=—OCO— or —COO— and R2 is an hydrogen atom or CH3;
• e)
• wherein:
• n1 and n2, R2, and X2 are as defined above;
• Y1 is —CH2—CH2— or —CH═CH— (CH2)n2-;
• f)
• wherein:
• n1 and R2 are as defined above, R3 is H or —COCH3;
• with the proviso that when Y is selected from the bivalent radicals mentioned under b)-f), the —ONO2 group is linked to a —(CH2)n1 group;
• g)
• wherein X3 is an oxygen atom or a sulphur atom,
• n3 is an integer from 1 to 6,
• R2 is a defined above;
• h)
• wherein:
• n4 is an integer from 0 to 10;
• n5 is an integer from 1 to 10;
• R4, R5, R6, R7 are the same or different, and are H or straight or branched C1-C4 alkyl, wherein the —ONO2 group is linked to
• wherein n5 is as defined above;
• Y2 is an heterocyclic saturated, unsaturated or aromatic 5 or 6 members ring, containing one or more heteroatoms selected from nitrogen, oxygen, sulfur, and is selected from