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US 2008/0293818 A1Published application
Regulator of Physiological Function of Ghrelin and Use Thereof
OwnerMasayasu Kojima, Yoshihiro Nishi +4inventors
InventorsMasayasu Kojima, Yoshihiro Nishi, Kenji Kanagawa, Keiichi Abe, Reiko Izumi, Junichi Nakamura
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Abstract
A regulator for regulating physiological functions, such as activity of increasing an intracellular calcium ion concentration, activity of promoting growth hormone secretion, activity of promoting eating, regulatory activity relating to fat accumulation, activity of ameliorating heart function and activity of stimulating gastric acid secretion, of ghrelin, which regulator comprises a fatty acid of carbon number 2-35 or its derivative, and use thereof.
Claims12
1:
- A regulator for regulating physiological functions of ghrelin, which comprises a fatty acid of carbon number 2 to 35 or its derivative.
2:
- The regulator according to claim 1, wherein the physiological function of ghrelin is activity of increasing intracellular calcium ion concentration, activity of promoting growth hormone secretion, activity of promoting eating, regulatory activity relating to fat accumulation, activity of ameliorating cardiac function or activity of stimulating gastric acid secretion.
3:
- A pharmaceutical composition comprising a regulator set forth in claim 1.
4:
- A functional food comprising a regulator set forth in claim 1.
5:
- An accelerator for the formation of activated ghrelin, which comprises at least one medium-chain fatty acid of 6 to 12 carbon number or its derivative.
6:
- The accelerator for the formation of activated ghrelin according to claim 5, which comprises at least one medium-chain fatty acid of 8 to 10 carbon number or its derivative.
7:
- A functional food containing an accelerator for the formation of activated ghrelin set forth in claim 5.
8:
- A composition characterized in that it contains a medium-chain fatty acid of 6 to 12 carbon number or its derivative and that it has muscle strengthening activity.
9:
- A composition comprising a medium-chain fatty acid of 6 to 12 carbon number or its derivative which has skin-beautification activity.
10:
- A method for preventing or treating disorders associated with physiological functions of ghrelin, which comprises administering an effective amount of a regulator set forth in claim 1., a pharmaceutical composition set forth in claim 3 or a functional food set forth in claim 4 to a subject in need thereof.
11:
- A method for preventing or treating disorders associated with physiological functions of ghrelin, which comprises administering an effective amount of a pharmaceutical composition as set forth in claim 3.
12:
- A method for preventing or treating disorders associated with physiological functions of ghrelin, which comprises administering an effective amount of a functional food as set forth in claim 4 to a subject in need thereof.