Substituted benzothiazole kinase inhibitors

A compound of formula (I)

• and forms thereof, wherein
• R1 is hydrogen or is selected from C1-6alkyl, C1-6alkoxy, amino, halogen, cyano, amino-sulfonyl, C1-4alkyl-amino-sulfonyl, halo-C1-4alkyl or halo-C1-4alkoxy;
• R2 is hydrogen or is selected from aryl, heteroaryl, heterocyclyl or C3-12cycloalkyl optionally substituted with one or two substituents selected from C1-6alkyl, C1-6alkoxy or halogen;
• R3 is hydrogen or is C1-4alkyl;
• X is selected from carbonyl, amino-carbonyl, oxy-carbonyl or sulfonyl;
• and
• R4 is selected from a C1-4alkyl, aryl, aryl-C1-4alkyl, heteroaryl, heteroaryl-C1-4alkyl, heterocyclyl, heterocyclyl-C1-4alkyl, C3-12cycloalkyl or C3-12cycloalkyl-C1-4alkyl optionally substituted on aryl, heteroaryl, heterocyclyl or C3-12cycloalkyl with one, two or three substituents selected from C1-6alkyl, C1-6alkenyl, C1-6alkynyl, C1-6alkoxy, C1-6alkyl-carbonyl, C1-6alkoxy-carbonyl, amino, halogen, cyano, nitro, amino-sulfonyl, halo-C1-4alkyl, halo-C1-4alkoxy, aryl, heteroaryl, heterocyclyl or C3-12cycloalkyl.