4,4-disubstituted piperidine derivatives

A compound of formula I:

• wherein
• R1 is selected from the group consisting of C2-7-alkyl, C2-7-alkenyl, C3-7-alkinyl, C3-7-cycloalkyl, halogen-C1-7-alkyl, C1-7-alkoxy-C1-7-alkyl and benzyl;
• R2 is selected from the group consisting of hydrogen, C1-7-alkyl,
• hydroxy, C1-7-alkoxy, C2-7-alkenyloxy,
• hydroxy-C1-7-alkoxy, C1-7-alkoxy-C1-7-alkoxy,
• —O-benzyl, —O—C3-7-cycloalkyl,
• halogen, halogen-C1-7-alkyl, halogen-C1-7-alkoxy,
• amino, pyrrolyl, imidazolyl,
• —C(O)OR6, wherein R6 is C1-7-alkyl, and
• unsubstituted phenyl or phenyl substituted by one to three groups independently selected from C1-7-alkyl, halogen and C1-7-alkoxy;
• R3 is hydrogen or C1-7-alkoxy;
• R4 is —NH—CO—R7, wherein R7 is a ring selected from phenyl or pyridyl, said ring being unsubstituted or substituted by one or two groups selected from C1-7-alkyl or halogen;
• R5 is —CO—NH2 or —CN;
• or R4 and R5 are bonded to each other to form a ring together with the carbon atom to which they are attached, and R4 and R5 together are:
• —NH—C(O)—NH—C(O)—,
• —C(O)—NR8—CH2—CH2—, wherein R8is phenyl, or
• —N═CR9—NH—C(O)—, wherein R9 is phenyl;
• and pharmaceutically acceptable salts thereof.