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US 2008/0293733 A1Published application
Axl kinase inhibitors
AssigneeSuperGen, Inc.
InventorsDavid J. Bearss, Hariprasad Vankayalapati, Yong Xu
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Abstract
Axl kinase inhibitory compounds are disclosed, as well as compositions and methods of using the same in the treatment of cancer and other conditions mediated by and/or associated with Axl kinase.
Claims18
A compound according to Formula (I):
- including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein:
- ring moiety A is selected from:
- and wherein:
- L1 is —NH—, —C(═S)NH—, —C(═S)NHS(═O)2—, or —C(═O)NH—;
- R1 is optional and if present is piperazinyl;
- L2=—S(═O)2NH—, —S(═O)2— or —NH—;
- R2 is heterocycle, substituted heterocycle, or —C(═O)R where R is alkyl;
- X is O, S or NH;
- Y at each occurrence is independently halo, haloalkyl or alkoxy;
- m is 0, 1, 2 or 3;
- R3 is —H, halo, haloalkyl, haloalkoxy, aryl or substituted aryl;
- and
- R4 is —H, alkyl, substituted alkyl, aryl or substituted aryl, heteroaryl or substituted heteroaryl.
10 more elements
Dependencies are inferred from the claim text.