Pyrimidine Derivatives

A compound of formula I

• wherein
• R0 is hydrogen
• R1 is a unsubstituted or substituted 6 member mono cyclic or a 10 member bicyclic-heterocycle comprising 1 or 2 heteroatoms independently selected from N and O;
• R2 and R3 together with the C and N to which they are attached form a heterocycle comprising at least 1 hetero atoms independently selected from N which is unsubstituted or substituted once or more by a substituent independently selected from loweralkyl and oxo;
• R4 is hydrogen
• R5 is halogen
• R6 is hydrogen
• R7 is hydrogen;
• R8 is hydrogen;
• C1-C7alkoxy;
• carbornyl unsubstituted or substituted by C1-C7alkyl;
• C1-C7alkoxy-C1-C7alkoxy;
• a 5 or 6 member heterocycle comprising 1, 2 hetero atoms independently selected from N or O and is unsubstituted or substituted by a substituent independently selected from hydroxy, C1-C7alkyl, mono or di-C1-C7alkylamino, a 6 member heterocycle comprising 1 or 2 N ring atoms unsubstituted or substituted by C1-C7alkyl;
• 5 or 6 member heterocycle-C1-C7alkoxy comprising 1N ring atom unsubstituted or substituted by C1-C7alkyl;
• R9 is hydrogen;
• R10 is hydrogen, halogen or C1-C7alkoxy;
• or a salt thereof.