Combination of Polychitosamine and Fibrate for the Prevention and Treatment of Hyperlipidemia
AssigneeDNP Canada Inc.
InventorsAndre Aube, Ryszard Brzezinski, Gilles Dupuis, Jean-Guy Lehoux
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Abstract
The present invention relates to pharmaceutical compositions comprising a fibrate (e.g. ciprofibrate, gemfibrozil, benzafibrate, and fenofibrate) and a polychitosamine (e.g. chitosan) having molecular weights of less than 650 Kda and degrees of deacetylation of from 70% to 100%. Uses of said compositions for the treatment of hyperlipidemia and associated conditions (e.g. hypercholesterolemia, atherosclerosis, coronary heart disease and cardiovascular disease) or as functional foods are also disclosed.
Claims36
A pharmaceutical dosage form comprising in combination:
- a) an amount of fibrate;
- b) an amount of polychitosamine having a molecular weight ranging from about 30 kDa to about 50 kDa;
- and optionally
- c) a pharmaceutically acceptable carrier.
(canceled)
10-22. (canceled)
A functional food comprising an effective amount of polychitosamine having a molecular weight ranging from about 30 kDa to about 50 kDa and an effective amount of fibrate.
(canceled)
A kit for the prophylaxis or treatment of hyperlipidemia in a mammal, the kit comprising a plurality of daily doses of dosage forms of a fibrate and a polychitosamine having a molecular weight ranging from about 30 kDa to about 50 kDa together with a treatment regimen instructions.
Dependencies are inferred from the claim text.