Pharmaceutical Formulations, Methods, and Dosing Regimens for the Treatment and Prevention of Acute Coronary Syndromes
AssigneePfizer Inc.
InventorsCharles L. Bisgaier, Narendra D. Lalwani, Wendi V. Rodrigueza, Daniel Hartman, Jan Johansson
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Abstract
The invention provides methods and formulations for treating and preventing acute coronary syndromes. The methods of the instant invention provide safe and effective doses of an Apolipoprotein A-I Milano: phospholipid complex to reduce and stabilize atherosclerotic plaque. Pharmaceutical formulations of the Apo A-I Milano:phospholipid complexes are also provided.
Claims24
1-39. (canceled)
A pharmaceutical formulation comprising a recombinant Apo AI Milano or variant thereof/1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine complex in a buffer.
50-53. (canceled)
A pharmaceutical formulation comprising a recombinant Apo A-I Milano, or variant thereof, complexed with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, and a phosphate buffer having a pH of about 7.0 to about 7.8, said buffer comprising 2% glucose and 4 mM of sodium phosphate.
58-64. (canceled)
A lyophilized pharmaceutical formulation comprising:
- a) recombinant Apo A-I Milano, or variant thereof, complexed with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine;
- b) about 6.0% to about 6.4% sucrose;
- and c) about 0.8 to about 1% mannitol.
66-67. (canceled)
72-78. (canceled)
Dependencies are inferred from the claim text.