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US 2008/0293117 A1Published application
Heat resistant bioactive composition
AssigneesToyota Motor Engineering & Manufacturing North America, Inc., Toyota Motor Corporation
InventorsPing Wang, Songtao Wu, Hongfei Jia, Masahiko Ishii, Xiaodong Tong, Minjuan Zhang
Life of this patent
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Abstract
A bioactive composition includes a hydrogel matrix. At least one protein is immobilized in the hydrogel matrix. The digestive protein has a half-life at least 1000 times longer than the half-life of a free digestive protein counterpart.
Claims12
A bioactive composition comprising:
- a porous hydrogel matrix;
- at least one protein immobilized in the porous hydrogel matrix, the protein having a half-life at least 1000 times longer than the half-life of a free digestive protein counterpart.
A process for stabilizing a bioactive composition comprising:
- forming hydrogel matrix pores around protein molecules;
- and
- reducing a water content within the hydrogel matrix pores while keeping the protein molecules biologically active.
A bioactive composition comprising:
- a hydrogel matrix pore defining a volume V1;
- at least one protein immobilized in the hydrogel matrix pore, wherein the protein has a total volume V2 defined by the collective three-dimensional size of the protein wherein the ratio of (V1−V2)/V1 is less than 20 percent.
Dependencies are inferred from the claim text.