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AssigneeHealth Reseach, Inc.
InventorsJohn R. Subjeck, Robert A. Henderson, Elizabeth A. Repasky, Latif Kazim, Xiang-Yang Wang, Masoud H. Manjili
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Pharmaceutical compositions comprising a stress protein complex and related molecules encoding or cells presenting such a complex are provided. The stress protein complex comprises an hsp110 or grp170 polypeptide complexed with an immunogenic polypeptide. The immunogenic polypeptide of the stress protein complex can be associated with a cancer or an infectious disease. Preferred immunogenic polypeptides include gp100, her2/neu ECD-PD, ICD and M. tuberculosis antigens. The pharmaceutical compositions of the invention can be used for the treatment or prevention of cancer or infectious disease.
A method of producing a stress protein complex, the method comprising:
A target cell that expresses an antigen of interest and that has been transfected with a vector whose expression product is a hsp110 or grp170 polypeptide;
Dependencies are inferred from the claim text.