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US 2008/0293102 A1Published application
Compositions and methods for producing apolipoprotein
AssigneeCerenis Therapeutics Holding, S.A.
InventorsMaritza OXENDER, Jean-Louis Dasseux
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Abstract
The disclosure relates to recombinant nucleic acids, expression vectors comprising the recombinant nucleic acids, and host cells comprising the expression vectors for expressing a protein of interest.
Claims53
A recombinant nucleic acid comprising:
- (i) a first polynucleotide sequence encoding a signal peptide comprising the structure:
- (n)x˜(m)y˜(c)z,
- wherein
- each n is independently any amino acid, with two or more n being a basic amino acid residue.
- each m is independently an aromatic, aliphatic, hydrophobic, or hydroxyl containing amino acid residue;
- each c is independently any amino acid, with two or more c being a polar amino acid residue;
- x is 6, 7, or 8;
- y is any integer from 13 to 16;
- and
- z is any integer from 5 to 14;
- “˜” is a peptide bond;
- and
- (ii) a second polynucleotide sequence encoding an apolipoprotein,
- wherein the first polynucleotide and the second polynucleotide are operably linked to direct secretion of the encoded apolipoprotein.
11 more elements
Dependencies are inferred from the claim text.