Engineered microorganisms for increasing product yield in biotransformations, related methods and systems
OwnerMatthew W. Peters, Peter Meinhold +2inventors
InventorsMatthew W. Peters, Peter Meinhold, Thomas Buelter, Marco Landwehr
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Abstract
There are disclosed recombinant microorganisms engineered to increase product yield in a biotransformation. In an embodiment, the microorganisms are engineered to increase the amount of NAD(P)H available for a NAD(P)H-requiring oxidoreductase involved in a biotransformation. There are also disclosed methods and systems for using recombinant microorganisms engineered to increase the amount of NAD(P)H available for a NAD(P)H-requiring oxidoreductase involved in a biotransformation. Other embodiments are also disclosed.
Claims30
A recombinant microorganisms engineered to increase the amount of NAD(P)H available for a biotransformation NAD(P)H-requiring oxidoreductase, the biotransformation NAD(P)H-requiring oxidoreductase involved in a biotransformation of a substrate to a product in the recombinant microorganism, wherein the recombinant microorganism is engineered to inactivate a respiratory pathway in the microorganism.
A recombinant microorganisms engineered to increase the amount of NAD(P)H available for a biotransformation NAD(P)H-requiring oxidoreductase, biotransformation NAD(P)H-requiring oxidoreductase involved in a biotransformation of a substrate to a product in the recombinant microorganism, wherein the recombinant microorganism is engineered to activate TCA cycle pathway in the microorganism.
Dependencies are inferred from the claim text.