Treatment of graft-versus-host disease with il-10 expressing cells
OwnerSun Uk SONGinventor
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Abstract
This present application describes a therapeutic agent for treating acute or chronic graft-versus-host disease using clonal marrow stem cells (cMSCs) as active ingredient.
Claims12
A therapeutic agent for treating acute or chronic graft-versus-host disease comprising a homogeneous population of clonal marrow stem cells as the active ingredient.
A homogeneous population of clonal marrow stem cells, which express IL-10 at least about 5 fold greater than cells isolated using density centrifugation methods.
A homogeneous population of clonal marrow stem cells, which express IL-10 at least about 5 fold greater than cells isolated using density centrifugation methods, wherein the homogeneous population of clonal marrow stem cells is obtained by
- (i) allowing a sample of bone marrow cells to settle in a container;
- (ii) transferring supernatant from the container to another container;
- and
- (iii) isolating cells from the supernatant, which has comparatively lower density in the sample.
Dependencies are inferred from the claim text.