Pharmaceutical compositions comprising peranhydrocyclodextrin
OwnerLajos Szente, Jozsef Szejtli +3inventors
InventorsLajos Szente, Jozsef Szejtli, Laszlo Jicsinszky, Georg Ludwig Kis, Christian Schoch
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Abstract
The present invention relates to a pharmaceutical composition comprising a peranhydrocyclodextrin, a drug and a carrier, to the use of a peranhydrocyclodextrin as a drug transport enhancer (e.g. permeation enhancer), and to the use of a peranhydrocyclodextrin in the preparation of a pharmaceutical composition as a synergistic adjunctive system.
Claims10
A pharmaceutical composition comprising a per(3,6-anhydro)cyclodextrin, a pharmaceutically effective drug and a carrier.
Use of a per(3,6-anhydro)cyclodextrin in the enhancement of the bioavailability of a pharmaceutically effective drug.
Use of a per(3,6-anhydro)cyclodextrin in the manufacture of a medicament for the enhancement of the bioavailability of a pharmaceutically effective drug.
A method of improving drug permeability through a tissue, which method comprises the steps of:
- Conventionally admixing an effective amount of a per(3,6-anhydro)cyclodextrin, an effective amount of a drug, a carrier, and optionally one or more further ingredients selected from the group of buffers, tonicity enhancing agents, preservatives, solubilizers. stabilizers/solubilizers, and complexing agents;
- and
- administering said pharmaceutical composition comprising said per(3,6-anhydro)cyclodextrin to said tissue.
Method of enhancing the bioavailability of a pharmaceutically effective drug, which method comprises conventionally admixing an effective amount of a per(3,6-anhydro)cyclodextrin, an effective amount of a drug, and a carrier.
Dependencies are inferred from the claim text.