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US 2008/0287516 A1Published application
Phenyl-Substituted Pyrrolidones
AssigneeIrm LLC
InventorsBaogen Wu, Truc Ngoc Nguyen, David Archer Ellis, Xiaohui He, Beth Marie Anaclerio, Kunyong Yang, Ha-soon Choi, Zhicheng Wang, Thomas H. Marsilje, Yun He
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Abstract
The present invention relates to phenyl-substituted pyrrolidones and compounds related to phenyl-substituted pyrrolidones. One use of these compounds is for the inhibition of viruses, e.g., HIV. The invention further relates to methods of malting these compounds, methods of identifying the efficacy of these compounds, and methods of using these compounds to inhibit or prevent HIV infection and related disease states such as AIDS.
Claims23
A compound having the formula:
- wherein R1 and R5 are members independently selected from H, CN, halogen, substituted or unsubstituted C1-C4 alkyl, substituted or unsubstituted C2-C4 alkenyl and OR8;
- wherein R8 is a member selected from substituted or unsubstituted C1-C4 alkyl and C1-C4 haloalkyl;
- R2 and R4 are members selected from H, halogen, CN, and substituted or unsubstituted C1-C4 alkyl;
- R3 is a member selected from H, CN, and alkyl;
- R6 is a member selected from a fused phenyl heterocyclic ring system and:
- wherein R9 and R11 are members independently selected from H, CN, C(O)NR12R12, NR12R12 and OR12;
- wherein R12 is a member selected from H, and substituted or unsubstituted C1-C4 alkyl;
- R10 is a member selected from CN, NR13R14, SO2NHR13, NHSO2R13, SO2NH(CH2)nOR13, SO2NH(CH2)nNR13R14, O(CH2)nSO2NHR13, O(CH2)nNR13R14, O(CH2)nSO2R5, SO2R5, SO2(CH2)nNR13R14 and C(O)NR13R14;
- wherein R13 and R14 are members selected from H and substituted or unsubstituted C1-C4 alkyl and, together with the nitrogen to which they are attached are optionally joined to form a heterocyclic ring;
- R15 is substituted or unsubstituted C1-C4 alkyl;
- n is an integer from 1 to 8;
- wherein at least one member selected from R9 and R11 is other than H;
- and
- R7 is a member selected from halogen, C1-C4 alkyl, C2-C4 alkenyl and C2-C4 alkynyl.
11 more elements
21-22. (canceled)
Dependencies are inferred from the claim text.