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US 2008/0287464 A1Published application
Depot Formulations
OwnerJeremy C. Wright, Felix Theeuwes +3inventors
InventorsJeremy C. Wright, Felix Theeuwes, John W. Gibson, Keith E. Branham, Stefania Sjobeck
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Abstract
Disclosed are formulations and related methods that comprise a non-polymeric, non-water soluble high viscosity liquid carrier material having a viscosity of at least 5,000 cP at 37° C. that does not crystallize neat under ambient or physiological conditions; a specified linear polymer comprising lactide repeat units; and one or more solvents that have a solvent capacity.
Claims40
A formulation comprising:
- (i) a non-polymeric, non-water soluble high viscosity liquid carrier material having a viscosity of at least 5,000 cP at 37° C. that does not crystallize neat under ambient or physiological conditions;
- (ii) a linear polymer comprising lactide repeat units, wherein the linear polymer possesses a ratio R of lactide repeat units to total repeat units in the linear polymer;
- and
- (iii) one or more solvents that have a solvent capacity;
- wherein the linear polymer has a weight average molecular weight less than or equal to about 15,000 Daltons, and
- wherein
- (a) R satisfies the following:
- about 0.55≦R≦about 0.95;
- (b) when R satisfies the following:
- about 0.55≦R≦0.85, the solvent capacity of the one or more solvents is greater than or equal to about 20%;
- and
- (c) when R satisfies the following:
- greater than about 0.85 to about 0.95, the solvent capacity of the one or more solvents is greater than or equal to about 10%.
10 more elements
A formulation comprising:
- (i) a non-polymeric, non-water soluble high viscosity liquid carrier material having a viscosity of at least 5,000 cP at 37° C. that does not crystallize neat under ambient or physiological conditions;
- (ii) a linear polymer comprising lactide repeat units, wherein the linear polymer possesses a ratio R of lactide repeat units to total repeat units in the linear polymer;
- and
- (iii) one or more solvents that have a solvent capacity;
- wherein the linear polymer has a weight average molecular weight less than or equal to about 15,000 Daltons, and
- wherein:
- (a) R satisfies the following:
- about 0.55≦R≦0.85;
- and
- (b) the solvent capacity of the one or more solvents is greater than or equal to about 20%.
7 more elements
A formulation comprising:
- (i) a non-polymeric, non-water soluble high viscosity liquid carrier material having a viscosity of at least 5,000 cP at 37° C. that does not crystallize neat under ambient or physiological conditions;
- (ii) a linear polymer comprising lactide repeat units, wherein the linear polymer possesses a ratio R of lactide repeat units to total repeat units in the linear polymer;
- and
- (iii) one or more solvents that have a solvent capacity;
- wherein the linear polymer has a weight average molecular weight less than or equal to about 15,000 Daltons, and
- wherein
- (a) R satisfies the following:
- greater than about 0.85 to about 0.95;
- and
- (b) the solvent capacity of the one or more solvents is greater than or equal to about 10%.
7 more elements
A formulation comprising:
- (i) a non-polymeric, non-water soluble high viscosity liquid carrier material having a viscosity of at least 5,000 cP at 37° C. that does not crystallize neat under ambient or physiological conditions;
- (ii) a linear polymer comprising lactide repeat units, wherein the linear polymer possesses a ratio R of lactide repeat units to total repeat units in the linear polymer, wherein R satisfies the following:
- about 0.55≦R≦about 0.95;
- and
- (iii) one or more solvents present in an amount ranging from about one weight percent up to about 35 weight percent, based on the total weight of the formulation;
- wherein the linear polymer has a weight average molecular weight less than or equal to about 15,000 Daltons, and
- wherein the one or more solvents comprise ethanol, ethyl lactate, propylene carbonate, glycofurol, N-methylpyrrolidone, 2-pyrrolidone, benzyl benzoate, miglyol, propylene glycol, acetone, methyl acetate, ethyl acetate, methyl ethyl ketone, benzyl alcohol, triacetin, dimethylformamide, dimethylsulfoxide, tetrahydrofuran, caprolactam, decylmethylsulfoxide, oleic acid, and/or 1-dodecylazacycloheptan-2-one, and combinations of any of the above.
4 more elements
Dependencies are inferred from the claim text.