Substituted Aminopyridines and Uses Thereof

A compound of formula Ia:

• or a pharmaceutically acceptable salt thereof wherein:
• Q is selected from C3-12cycloalkyl, C3-12cycloalkenyl, C5-14aryl and C5-14heterocyclyl;
• R1 is independently selected from H, OH, halogen, N(C1-4alkyl )2, NHC1-4alkyl, NH2, optionally substituted C1-6alkyl, optionally substituted OC1-6alkyl, optionally substituted C2-6alkenyl, optionally substituted C2-6alkynyl, optionally substituted C3-12cycloalkyl, optionally substituted C5-10aryl, optionally substituted C1-6alkyl-C5-10aryl, optionally substituted C5-10heterocyclyl and optionally substituted C1-6alkyl-C5-10heterocyclyl wherein such substituents is/are independently selected from:
• halogen, CN, NH2, OH, C1-6alkyl-Ra, OC1-6alkyl-Ra, C(═O)C1-6alkyl-Ra, C(═O)OC1-6alkyl-Ra, C(═O)NH2, C(═O)NHC1-6alkyl-Ra, C(═O)N(C1-6alkyl-Ra)2, SO2C1-6alkyl-Ra, SO2NHC1-6alkyl-Ra, SO2N(C1-6alkyl-Ra)2, NH(C1-6alkyl)-Ra, N(C1-6alkyl-Ra)2, NHC(═O)C1-6alkyl, NHC(═O)C1-6alkyl-Ra, NC(═O)(C1-6alkyl)2, C5-6aryl-Ra, OC5-6aryl-Ra, C(═O)C5-6aryl-Ra, C(═O)OC5-6aryl-Ra, C(═O)NH2, C(═O)NHC5-6aryl-Ra, C(═O)N(C5-6aryl-Ra)2, SO2C5-6aryl-Ra, SO2NHC5-6aryl-Ra, SO2N(C5-6aryl-Ra)2, NH(C5-6aryl)-Ra, N(C5-6aryl-Ra)2, NHC(═O)C5-6aryl, NC(═O)(C5-6aryl)2, C5-6heterocyclyl-Ra, OC5-6heterocyclyl-Ra, C(═O)C5-6heterocyclyl-Ra, C(═O)OC5-6heterocyclyl-Ra, C(═O)NH2, C(═O)NHC5-6heterocyclyl-Ra, C(═O)N(C5-6heterocyclyl-Ra)2, SO2C5-6heterocyclyl-Ra, SO2NHC5-6heterocyclyl-Ra, SO2N(C5-6heterocyclyl)2-Ra, NH(C5-6heterocyclyl)-Ra, N(C5-6heterocyclyl-Ra)2, NHC(═O)C5-6heterocyclyl, and NC(═O)(C5-6heterocyclyl)2;
• Ra is selected from H, halogen, CN, NH2, OH, C1-6alkyl, OC1-6alkyl, OC1-6alkyl-OC1-6alkyl, C(═O)C1-6alkyl, C(═O)OC1-6alkyl, OC(═O)C1-6alkyl, C(═O)NH2, C(═O)NHC1-6alkyl, C(═O)N(C1-6alkyl)2, SO2C1-6alkyl, SO2NHC1-6alkyl, SO2N(C1-6alkyl)2, NH(C1-6alkyl), N(C1-6alkyl)2, NHC(═O)C1-6alkyl, NC(═O)(C1-6alkyl)2,_NHC3-12cycloalkyl, N(C3-12cycloalkyl)2, NHC(═O)C3-12cycloalkyl, NC(═O)(C3-12cycloalkyl)2, C5-6aryl, OC5-6aryl, C(═O)C5-6aryl, C(═O)OC5-6aryl, C(═O)NH2, C(═O)NHC5-6aryl, C(═O)N(C5-6aryl)2, SO2C5-6aryl, SO2NHC5-6aryl, SO2N(C5-6aryl)2, NH(C5-6aryl), N(C5-6aryl)2, NHC(═O)C5-6aryl, NC(═O)(C5-6aryl)2, C5-6heterocyclyl, OC5-6heterocyclyl, C(═O)C5-6heterocyclyl, C(═O)OC5-6heterocyclyl, C(═O)NH2, C(═O)NHC5-6heterocyclyl-, C(═O)N(C5-6heterocyclyl)2, SO2C5-6heterocyclyl, SO2NHC5-6heterocyclyl, SO2N(C5-6heterocyclyl)2NH(C5-6heterocyclyl), N(C5-6heterocyclyl)2, NHC(═O)C5-6heterocyclyl, and NC(═O)(C5-6heterocyclyl)2;
• V is independently selected from N, O, S, SO, SO2, NHSO2, SO2NH, NHC(═O), C(═O)NH, and optionally substituted C1-6alkyl wherein such substituent is/are independently selected from R2;
• X is selected from N, O, S, SO, SO2, NHSO2, SO2NH, NHC(═O), C(═O)NH, and optionally substituted C1-6alkyl, C2-6alkenyl or C3-5cycloalkyl wherein such substituent is/are independently selected from R2;
• Y is selected from N, O, S, SO, SO2, NHSO2, SO2NH, NHC(═O), C(═O)NH, and optionally substituted C1-6alkyl or C3-5cycloalkyl wherein such substituent is/are independently selected from R2;
• Z is selected from N, O, S, SO, SO2, NHSO2, SO2NH, NHC(═O), C(═O)NH, and optionally substituted C1-6alkyl or C3-5cycloalkyl wherein such substituent is/are independently selected from R2;
• k is 0, 1, 2, 3 or 4;
• m is 0, 1, 2, 3 or 4;
• n is 0, 1, 2, 3 or 4;
• q is 0 or 1;
• r is 0 or 1;
• s is 0 or 1;
• t is 0, 1 or 2;
• where at least one of s, r or q are 1.
• R2 is independently selected from H, halogen, optionally substituted C1-6alkyl, optionally substituted O—C1-6alkyl, optionally substituted C3-12cycloalkyl, optionally substituted C5-10aryl, optionally substituted C1-6alkyl-C5-10aryl, optionally substituted C5-10heterocyclyl and optionally substituted C1-6alkyl-C5-10heterocyclyl wherein such substituent are independently selected from:
• halogen, CN, NH2, OH, C1-6alkyl-Ra, OC1-6alkyl-Ra, C(═O)C1-6alkyl-Ra, C(═O)OC1-6alkyl-Ra, C(═O)NH2, C(═O)NHC1-6alkyl-Ra, C(═O)N(C1-6alkyl)2-Ra, SO2C1-6alkyl-Ra, SO2NHC1-6alkyl-Ra, SO2N(C1-6alkyl)2-Ra, NH(C1-6alkyl)-Ra, N(C1-6alkyl)2-Ra, NHC(═O)C1-6alkyl, NC(═O)(C1-6alkyl)2, C5-6aryl-Ra, OC5-6aryl-Ra, C(═O)C5-6aryl-Ra, C(═O)OC5-6aryl-Ra, C(═O)NH2, C(═O)NHC5-6aryl-Ra, C(═O)N(C5 6aryl)2-Ra, SO2C5-6aryl-Ra, SO2NHC5-6aryl-Ra, SO2N(C5-6aryl)2-Ra, NH(C5-6aryl)-Ra, N(C5-6aryl)2-Ra, NHC(═O)C5-6aryl, NC(═O)(C5-6aryl)2, C5-6heterocyclyl-Ra, OC5-6heterocyclyl-Ra, C(═O)C5-6heterocyclyl-Ra, C(═O)OC5-6heterocyclyl-Ra, C(═O)NH2, C(═O)NHC5-6heterocyclyl-Ra, C(═O)N(C5-6heterocyclyl)2-Ra, SO2NHC5-6heterocyclyl-Ra, SO2N(C5-6heterocyclyl)2-Ra, NH(C5-6heterocyclyl)-Ra, N(C5-6heterocyclyl)2-Ra, NHC(═O)C5-6heterocyclyl, and NC(═O)(C5-6heterocyclyl)2;
• R3 is independently selected from H, halogen, CN, NH2, OH, C1-6alkyl-Ra, C2-6alkenyl-Ra, C2-6alkynyl-Ra, C5-6cycloalkenyl-Ra, C3-12cycloalkyl-Ra, C1-6alkyl-C3-12cycloalkyl-Ra, C5-10aryl-Ra, C1-6alkyl-C5-10aryl-Ra, C5-10heterocyclyl-Ra, C1-6alkyl-C5-10heterocyclyl-Ra, C(═O)C5-6heterocyclyl-Ra, C(═O)C5-10aryl-Ra, C(═O)C3-12cycloalkyl-Ra, OC1-6alkyl-Ra, O—C5-10aryl-Ra, O—C5-6heterocyclyl-Ra, O—C3-12cycloalkyl-Ra, C(═O)OC1-6alkyl-Ra, C(═O)NH2, C(═O)NHC1-6alkyl-Ra, C(═O)N(C1-6alkyl)2-Ra, SO2C1-6alkyl-Ra, SO2NHC1-6alkyl-Ra, SO2N(C1-6alkyl)2-Ra, NH(C1-6alkyl)-Ra, N(C1-6alkyl)2-Ra, NHC(═O)C1-6alkyl, NC(═O)(C1-6alkyl)2, NHC(═O)NHC1-6alkyl, NHC(═O)OC1-6alkyl, C5-6aryl-Ra, OC5-6aryl-Ra, C(═O)C5-6aryl-Ra, C(═O)OC5-6aryl-Ra, C(═O)NH2, C(═O)NHNH2, C(═O)NHC5-6aryl-Ra, C(═O)N(C5-6aryl)2-Ra, SO2C5-6aryl-Ra, SO2NHC5-6aryl-Ra, SO2N(C5-6aryl)2-Ra, NH(C5-6aryl)-Ra, NH(C5-6aryl)-Ra, N(C5-6aryl)2-Ra, NHC(═O)C5-6aryl, NC(═O)(C5-6aryl)2, NHC(═O)NHC5-6aryl, NHC(═O)OC5-6aryl, C5-6heterocyclyl-Ra, OC5-6heterocyclyl-Ra, C(═O)C5-6heterocyclyl-Ra, C(═O)OC5-6heterocyclyl-Ra, C(═O)NH2, C(═O)NHC5-6heterocyclyl-Ra, C(═O)N(C5-6heterocyclyl)2-Ra, SO2C5-6heterocyclyl-Ra, SO2NHC5-6heterocyclyl-R, SO2N(C5-6heterocyclyl)2-Ra, NH(C5-6heterocyclyl)-Ra, N(C5-6heterocyclyl)2-Ra, NHC(═O)C5-6heterocyclyl, NC(═O)(C5-6heterocyclyl)2, NHC(═O)NHC5-6heterocyclyl, and NHC(═O)OC5-6heterocyclyl;
• R4 is independently selected from H, OH, halogen, N(C1-4alkyl )2, NHC1-4alkyl, NH2, optionally substituted C1-6alkyl, optionally substituted OC1-6alkyl, optionally substituted C2-6alkenyl, optionally substituted C2-6alkynyl, optionally substituted C3-12cycloalkyl, optionally substituted C5-10aryl, optionally substituted C1-6alkyl-C5-10aryl, optionally substituted C5-10heterocyclyl and optionally substituted C1-6alkyl-C5-10heterocyclyl wherein such substituents is/are independently selected from:
• halogen, CN, NH2, OH, C1-6alkyl-Ra, OC1-6alkyl-Ra, C(═O)C1-6alkyl-Ra, C(═O)OC1-6alkyl-Ra, C(═O)NH2, C(═O)NHC1-6alkyl-Ra, C(═O)N(C1-6alkyl-Ra)2, SO2C1-6alkyl-Ra, SO2NHC1-6alkyl-Ra, SO2N(C1-6alkyl-Ra)2, NH(C1-6alkyl)-Ra, N(C1-6alkyl-Ra)2, NHC(═O)C1-6alkyl, NHC(═O)C1-6alkyl-Ra, NC(═O)(C1-6alkyl)2, C5-6aryl-R, OC5-6aryl-Ra, C(═O)C5-6aryl-Ra, C(═O)OC5-6aryl-Ra, C(═O)NH2, C(═O)NHC5-6aryl-Ra, C(═O)N(C5-6aryl-Ra)2, SO2C5-6aryl-Ra, SO2NHC5-6aryl-Ra, SO2N(C5-6aryl-Ra)2, NH(C5-6aryl)-Ra, N(C5-6aryl-Ra)2, NHC(═O)C5-6aryl, NC(═O)(C5-6aryl)2, C5-6heterocyclyl-Ra, OC5-6heterocyclyl-Ra, C(═O)C5-6heterocyclyl-Ra, C(═O)OC5-6heterocyclyl-Ra, C(═O)NH2, C(═O)NHC5-6heterocyclyl-Ra, C(═O)N(C5-6heterocyclyl-Ra)2, SO2C5-6heterocyclyl-Ra, SO2NHC5-6heterocyclyl-Ra, SO2N(C5-6heterocyclyl)2-Ra, NH(C5-6heterocyclyl)-Ra, N(C5-6heterocyclyl-Ra)2, NHC(═O)C5-6heterocyclyl, and NC(═O)(C5-6heterocyclyl)2.

A compound of formula Ib:

• or a pharmaceutically acceptable salt thereof wherein:
• Q is selected from C3-12cycloalkyl, C3-12cycloalkenyl, C5-14aryl and C5-14heterocyclyl;
• R1 is independently selected from H, OH, halogen, N(C1-4alkyl )2, NHC1-4alkyl, NH2, optionally substituted C1-6alkyl, optionally substituted OC1-6alkyl, optionally substituted C2-6alkenyl, optionally substituted C2-6alkynyl, optionally substituted C3-12cycloalkyl, optionally substituted C5-10aryl, optionally substituted C1-6alkyl-C5-10aryl, optionally substituted C5-10heterocyclyl and optionally substituted C1-6alkyl-C5-10heterocyclyl wherein such substituents is/are independently selected from:
• halogen, CN, NH2, OH, C1-6alkyl-Ra, OC-1-6alkyl-Ra, C(═O)C1-6alkyl-Ra, C(═O)OC1-6alkyl-Ra, C(═O)NH2, C(═O)NHC1-6alkyl-Ra, C(═O)N(C1-6alkyl-Ra)2, SO2C1-6alkyl-Ra, SO2NHC1-6alkyl-Ra, SO2N(C1-6alkyl-Ra)2, NH(C1-6alkyl)-Ra, N(C1-6alkyl-Ra)2, NHC(═O)C1-6alkyl, NHC(═O)C1-6alkyl-Ra, NC(═O)(C1-6alkyl)2, C5-6aryl-Ra, OC5-6aryl-Ra, C(═O)C5-6aryl-Ra, C(═O)OC5-6aryl-Ra, C(═O)NH2, C(═O)NHC5-6aryl-Ra, C(═O)N(C5-6aryl-Ra)2, SO2C5-6aryl-Ra, SO2NHC5-6aryl-Ra, SO2N(C5-6aryl-Ra)2, NH(C5-6aryl)-Ra, N(C5-6aryl-Ra)2, NHC(═O)C5-6aryl, NC(═O)(C5-6aryl)2, C5-6hetercyclyl-Ra, OC5-6heterocyclyl-Ra, C(═O)C5-6heterocyclyl-Ra, C(═O)OC5-6heterocyclyl-Ra, C(═O)NH2, C(═O)NHC5-6heterocyclyl-Ra, C(═O)N(C5-6heterocyclyl-Ra)2, SO2C5-6heterocyclyl-Ra, SO2NHC5-6heterocyclyl-Ra, SO2N(C5-6heterocyclyl)2-Ra, NH(C5-6heterocyclyl)-Ra, N(C5-6heterocyclyl-Ra)2, NHC(═O)C5-6heterocyclyl, and NC(═O)(C5-6heterocyclyl)2;
• Ra is selected from H, halogen, CN, NH2, OH, C1-6alkyl, OC1-6alkyl, OC1-6alkyl-OC1-6alkyl, C(═O)C1-6alkyl, C(═O)OC1-6alkyl, OC(═O)C1-6alkyl, C(═O)NH2, C(═O)NHC1-6alkyl, C(═O)N(C1-6alkyl)2, SO2C1-6alkyl, SO2NHC1-6alkyl, SO2N(C1-6alkyl)2, NH(C1-6alkyl), N(C1-6alkyl)2, NHC(═O)C1-6alkyl, NC(═O)(C1-6alkyl)2, NHC3-12cycloalkyl, N(C3-12cycloalkyl)2, NHC(═O)C3-12cycloalkyl, NC(═O)(C3-12cycloalkyl)2, C5-6aryl, OC5-6aryl, C(═O)C5-6aryl, C(═O)OC5-6aryl, C(═O)NH2, C(═O)NHC5-6aryl, C(═O)N(C5-6aryl)2, SO2C5-6aryl, SO2NHC5-6aryl, SO2N(C5-6aryl)2, NH(C5-6aryl, N(C5-6aryl)2, NHC(═O)C5-6aryl, NC(═O)(C5-6aryl)2, C5-6heterocyclyl, OC5-6heterocyclyl, C(═O)C5-6heterocyclyl, C(═O)OC5-6heterocyclyl, C(═O)NH2, C(═O)NHC5-6heterocyclyl-, C(═O)N(C5-6heterocyclyl)2, SO2C5-6heterocyclyl, SO2NHC5-6heterocyclyl, SO2N(C5-6heterocyclyl)2, NH(C5-6heterocyclyl), N(C5-6heterocyclyl)2, NHC(═O)C5-6heterocyclyl, and NC(═O)(C5-6heterocyclyl)2;
• V is independently selected from N, O, S, SO, SO2, NHSO2, SO2NH, NHC(═O), C(═O)NH, and optionally substituted C1-6alkyl wherein such substituent is/are independently selected from R2;
• X is selected from N, O, S, SO, SO2, NHSO2, SO2NH, NHC(═O), C(═O)NH, and optionally substituted C1-6alkyl, C2-6alkenyl or C3-5cycloalkyl wherein such substituent is/are independently selected from R2;
• Y is selected from N, O, S, SO, SO2, NHSO2, SO2NH, NHC(═O), C(═O)NH, and optionally substituted C1-6alkyl or C3-5cycloalkyl wherein such substituent is/are independently selected from R2;
• Z is selected from N, O, S, SO, SO2, NHSO2, SO2NH, NHC(═O), C(═O)NH, and optionally substituted C1-6alkyl or C3-5cycloalkyl wherein such substituent is/are independently selected from R2;
• k is 0, 1, 2, 3 or 4;
• m is 0, 1, 2, 3 or 4;
• n is 0, 1, 2, 3 or 4;
• q is 0 or 1;
• r is 0 or 1;
• s is 0 or 1;
• t is 0, or 1;
• where at least one of s, r or q are 1.
• R2 is independently selected from H, halogen, optionally substituted C1-6alkyl, optionally substituted O—C1-6alkyl, optionally substituted C3-12cycloalkyl, optionally substituted C5-10aryl, optionally substituted C1-6alkyl-C5-10aryl, optionally substituted C5-10heterocyclyl and optionally substituted C1-6alkyl-C5-10heterocyclyl wherein such substituent are independently selected from:
• halogen, CN, NH2, OH, C1-6alkyl-Ra, OC1-6alkyl-Ra, C(═O)C1-6alkyl-Ra, C(═O)OC1-6alkyl-Ra, C(═O)NH2, C(═O)NHC1-6alkyl-Ra, C(═O)N(C1-6alkyl)2-Ra, SO2C1-6alkyl-Ra, SO2NHC1-6alkyl-Ra, SO2N(C1-6alkyl)2-Ra, NH(C1-6alkyl)-Ra, N(C1-6alkyl)2-Ra, NHC(═O)C1-6alkyl, NC(═O)(C1-6alkyl)2, C5-6aryl-Ra, OC5-6aryl-Ra, C(═O)C5-6aryl-Ra, C(═O)OC5-6aryl-Ra, C(═O)NH2, C(═O)NHC5-6aryl-Ra, C(═O)N(C5-6aryl)2-Ra, SO2C5-6aryl-Ra, SO2NHC5-6aryl-Ra, SO2N(C5-6aryl)2-Ra, NH(C5-6aryl)-Ra, N(C5-6aryl)2-Ra, NHC(═O)C5-6aryl, NC(═O)(C5-6aryl)2, C5-6heterocyclyl-Ra, OC5-6heterocyclyl-Ra, C(═O)C5-6heterocyclyl-Ra, C(═O)OC5-6heterocyclyl-Ra, C(═O)NH2, C(═O)NHC5-6heterocyclyl-Ra, C(═O)N(C5-6heterocyclyl)2-Ra, SO2C5-6heterocyclyl-Ra, SO2NHC5-6heterocyclyl-Ra, SO2N(C5-6heterocyclyl)2-Ra, NH(C5-6heterocyclyl)-Ra, N(C5-6heterocyclyl)2-Ra, NHC(═O)C5-6heterocyclyl, and NC(═O)(C5-6heterocyclyl)2;
• R3 is independently selected from H, halogen, CN, NH2, OH, C1-6alkyl-Ra, C2-6alkenyl-Ra, C2-6alkynyl-Ra, C5-6cycloalkenyl-Ra, C3-12cycloalkyl-Ra, C1-6alkyl-C3-12cycloalkyl-Ra, C5-10aryl-Ra, C1-6alkyl-C5-10aryl-Ra, C5-10heterocyclyl-Ra, C1-6alkyl-C5-10heterocyclyl-Ra, C(═O)C5-6heterocyclyl-Ra, C(═O)C5-10aryl-Ra, C(═O)C3-12cycloalkyl-Ra, OC1-6alkyl-Ra, O—C5-10aryl-Ra, O—C5-6heterocyclyl-Ra, O—C3-12cycloalkyl-Ra, C(═O)OC1-6alkyl-Ra, C(═O)NH2, C(═O)NHC1-6alkyl-Ra, C(═O)N(C1-6alkyl)2-Ra, SO2C1-6alkyl-Ra, SO2NHC1-6alkyl-Ra, SO2N(C1-6alkyl)2-Ra, NH(C1-6alkyl)-Ra, N(C1-6alkyl)2-Ra, NHC(═O)C1-6alkyl, NC(═O)(C1-6alkyl)2, NHC(═O)NHC1-6alkyl, NHC(═O)OC1-6alkyl, C5-6aryl-Ra, OC5-6aryl-Ra, C(═O)C5-6aryl-Ra, C(═O)OC5-6aryl-Ra, C(═O)NH2, C(═O)NHNH2, C(═O)NHC5-6aryl-Ra, C(═O)N(C5-6aryl)2-Ra, SO2C5-6aryl-Ra, SO2NHC5-6aryl-Ra, SO2N(C5-6aryl)2-Ra, NH(C5-6aryl)-Ra, N(C5-6aryl)2-Ra, NHC(═O)C5-6aryl, NC(═O)(C5-6aryl)2, NHC(═O)NHC5-6aryl, NHC(═O)OC5-6aryl, C5-6heterocyclyl-Ra, OC5-6heterocyclyl-Ra, C(═O)C5-6heterocyclyl-Ra, C(═O)OC5-6heterocyclyl-Ra, C(═O)NH2, C(═O)NHC5-6heterocyclyl-Ra, C(═O)N(C5-6heterocyclyl)2-Ra, SO2C5-6heterocyclyl-Ra, SO2NHC5-6heterocyclyl-Ra, SO2N(C5-6heterocyclyl)2-Ra, NH(C5-6heterocyclyl)-Ra, N(C5-6heterocyclyl)2-Ra, NHC(═O)C5-6heterocyclyl, NC(═O)(C5-6heterocyclyl)2, NHC(═O)NHC5-6heterocyclyl, and NHC(═O)OC5-6heterocyclyl;
• R4 is independently selected from H, OH, halogen, N(C1-4alkyl )2, NHC1-4alkyl, NH2, optionally substituted C1-6alkyl, optionally substituted OC1-6alkyl, optionally substituted C2-6alkenyl, optionally substituted C2-6alkynyl, optionally substituted C3-12cycloalkyl, optionally substituted C5-10aryl, optionally substituted C1-6alkyl-C5-10aryl, optionally substituted C5-10heterocyclyl and optionally substituted C1-6alkyl-C5-6heterocyclyl wherein such substituents is/are independently selected from:
• halogen, CN, NH2, OH, C1-6alkyl-Ra, OC1-6alkyl-Ra, C(═O)C1-6alkyl-Ra, C(═O)OC1-6alkyl-Ra, C(═O)NH2, C(═O)NHC1-6alkyl-Ra, C(═O)N(C1-6alkyl-Ra)2, SO2C1-6alkyl-Ra, SO2NHC1-6alkyl-Ra, SO2N(C1-6alkyl-Ra)2, NH(C1-6alkyl)-Ra, N(C1-6alkyl-Ra)2, NHC(═O)C1-6alkyl, NHC(═O)C1-6alkyl-Ra, NC(═O)(C1-6alkyl)2, C1-6aryl-Ra, OC5-6aryl-Ra, C(═O)C5-6aryl-Ra, C(═O)OC5-6aryl-Ra, C(═O)NH2, C(═O)NHC5-6aryl-Ra, C(═O)N(C5-6aryl-Ra)2, SO2C5-6aryl-Ra, SO2NHC5-6aryl-Ra, SO2N(C5-6aryl-Ra)2, NH(C5-6aryl)-Ra, N(C5-6aryl-Ra)2, NHC(═O)C5-6aryl, NC(═O)(C5-6aryl)2, C5-6heterocyclyl-Ra, OC5-6heterocyclyl-Ra, C(═O)C5-6heterocyclyl-Ra, C(═O)OC5-6heterocyclyl-Ra, C(═O)NH2, C(═O)NHC5-6heterocyclyl-Ra, C(═O)N(C5-6heterocyclyl-Ra)2, SO2C5-6heterocyclyl-Ra, SO2NHC5-6heterocyclyl-Ra, SO2N(C5-6heterocyclyl)2-Ra, NH(C5-6heterocyclyl)-Ra, N(C5-6heterocyclyl-Ra)2, NHC(═O)C5-6heterocyclyl, and NC(═O)(C5-6heterocyclyl)2.

A compound of formula Ic:

• or a pharmaceutically acceptable salt thereof wherein:
• Q is selected from C3-12cycloalkyl, C3-12cycloalkenyl, C5-14aryl and C5-14heterocyclyl;
• R1 is independently selected from H, OH, halogen, N(C1-4alkyl )2, NHC1-4alkyl, NH2, optionally substituted C1-6alkyl, optionally substituted OC1-6alkyl, optionally substituted C2-6alkenyl, optionally substituted C2-6alkynyl, optionally substituted C3-12cycloalkyl, optionally substituted C5-10aryl, optionally substituted C1-6alkyl-C5-10aryl, optionally substituted C5-10heterocyclyl and optionally substituted C1-6alkyl-C5-10heterocyclyl wherein such substituents is/are independently selected from:
• halogen, CN, NH2, OH, C1-6alkyl-Ra, OC1-6alkyl-Ra, C(═O)C1-6alkyl-Ra, C(═O)OC1-6alkyl-Ra, C(═O)NH2, C(═O)NHC1-6alkyl-Ra, C(═O)N(C1-6alkyl-Ra)2, SO2C1-6alkyl-Ra, SO2NHC1-6alkyl-Ra, SO2N(C1-6alkyl-Ra)2, NH(C1-6alkyl)-Ra, N(C1-6alkyl-Ra)2, NHC(═O)C1-6alkyl, NHC(═O)C1-6alkyl-Ra, NC(═O)(C1-6alkyl)2, C5-6aryl-Ra, OC5-6aryl-Ra, C(═O)C5-6aryl-Ra, C(═O)OC5-6aryl-Ra, C(═O)NH2, C(═O)NHC5-6aryl-Ra, C(═O)N(C5-6aryl-Ra)2, SO2C5-6aryl-Ra, SO2NHC5-6aryl-Ra, SO2N(C5-6aryl-Ra)2, NH(C5-6aryl)-Ra, N(C5-6aryl-Ra)2, NHC(═O)C5-6aryl, NC(═O)(C5-6aryl)2, C5-6heterocyclyl-Ra, OC5-6heterocyclyl-Ra, C(═O)C5-6heterocyclyl-Ra, C(═O)OC5-6heterocyclyl-Ra, C(═O)NH2, C(═O)NHC5-6heterocyclyl-Ra, C(═O)C5-6heterocyclyl-Ra)2, SO2C5-6heterocyclyl-Ra, SO2NHC5-6heterocyclyl-Ra, SO2N(C5-6heterocyclyl)2-Ra, NH(C5-6heterocyclyl)-Ra, N(C5-6heterocyclyl-Ra)2, NHC(═O)C5-6heterocyclyl, and NC(═O)(C5-6heterocyclyl)2;
• Ra is selected from H, halogen, CN, NH2, OH, C1-6alkyl, OC1-6alkyl, OC1-6alkyl-OC1-6alkyl, C(═O)C1-6alkyl, C(═O)OC1-6alkyl, OC(═O)C1-6alkyl, C(═O)NH2, C(═O)NHC1-6alkyl, C(═O)N(C1-6alkyl)2, SO2C1-6alkyl, SO2NHC1-6alkyl, SO2N(C1-6alkyl)2, NH(C1-6alkyl), N(C1-6alkyl)2, NHC(═O)C1-6alkyl, NC(═O)(C1-6alkyl)2, NHC3-12cycloalkyl, N(C3-12cycloalkyl)2, NHC(═O)C3-12cycloalkyl, NC(═O)(C3-12cycloalkyl)2, C5-6aryl, OC5-6aryl, C(═O)C5-6aryl, C(═O)OC5-6aryl, C(═O)NH2, C(═O)NHC5-6aryl, C(═O)N(C5-6aryl)2, SO2C5-6aryl, SO2NHC5-6aryl, SO2N(C5-6aryl)2, NH(C5-6aryl), N(C5-6aryl)2, NHC(═O)C5-6aryl, NC(═O)(C5-6aryl)2, C5-6heterocyclyl, OC5-6heterocyclyl, C(═O)C5-6heterocyclyl, C(═O)OC5-6heterocyclyl, C(═O)NH2, C(═O)NHC5-6heterocyclyl-, C(═O)N(C5-6heterocyclyl)2, SO2C5-6heterocyclyl, SO2NHC5-6heterocyclyl, SO2N(C5-6heterocyclyl)2, NH(C5-6heterocyclyl), N(C5-6heterocyclyl)2, NHC(═O)C5-6heterocyclyl, and NC(═O)(C5-6heterocyclyl)2;
• V is independently selected from N, O, S, SO, SO2, NHSO2, SO2NH, NHC(═O), C(═O)NH, and optionally substituted C1-6alkyl wherein such substituent is/are independently selected from R2;
• X is selected from N, O, S, SO, SO2, NHSO2, SO2NH, NHC(═O), C(═O)NH, and optionally substituted C1-6alkyl, C2-6alkenyl or C3-5cycloalkyl wherein such substituent is/are independently selected from R2;
• Y is selected from N, O, S, SO, SO2, NHSO2, SO2NH, NHC(═O), C(═O)NH, and optionally substituted C1-6alkyl or C3-5cycloalkyl wherein such substituent is/are independently selected from R2;
• Z is selected from N, O, S, SO, SO2, NHSO2, SO2NH, NHC(═O), C(═O)NH, and optionally substituted C1-6alkyl or C3-5cycloalkyl wherein such substituent is/are independently selected from R2;
• k is 0, 1, 2, 3 or 4;
• m is 0, 1, 2, 3 or 4;
• n is 0, 1, 2, 3 or 4;
• q is 0 or 1;
• r is 0 or 1;
• s is 0 or 1;
• t is 0, 1 or 2;
• where at least one of s, r or q are 1.
• R2 is independently selected from H, halogen, optionally substituted C1-6alkyl, optionally substituted O—C1-6alkyl, optionally substituted C3-12cycloalkyl, optionally substituted C5-10aryl, optionally substituted C1-6alkyl-C5-10aryl, optionally substituted C5-10heterocyclyl and optionally substituted C1-6alkyl-C5-10heterocyclyl wherein such substituent are independently selected from:
• halogen, CN, NH2, OH, C1-6alkyl-Ra, OC1-6alkyl-Ra, C(═O)C1-6alkyl-Ra, C(═O)OC1-6alkyl-Ra, C(═O)NH2, C(═O)NHC1-6alkyl-Ra, C(═O)N(C1-6alkyl)2-Ra, SO2C1-6alkyl-Ra, SO2NHC1-6alkyl-Ra, SO2N(C1-6alkyl)2-Ra, NH(C1-6alkyl)-Ra, N(C1-6alkyl)2-Ra, NHC(═O)C1-6alkyl, NC(═O)(C1-6alkyl)2, C5-6aryl-Ra, OC5-6aryl-Ra, C(═O)C5-6aryl-Ra, C(═O)OC5-6aryl-Ra, C(═O)NH2, C(═O)NHC5-6aryl-Ra, C(═O)N(C5-6aryl)2-Ra, SO2C5-6aryl-Ra, SO2NHC5-6aryl-Ra, SO2N(C5-6aryl)2-Ra, NH(C5-6aryl)-Ra, N(C5-6aryl)2-Ra, NHC(═O)C5-6aryl, NC(═O)(C5-6aryl)2, C5-6heterocyclyl-Ra, OC5-6heterocyclyl-Ra, C(═O)C5-6heterocyclyl-Ra, C(═O)OC5-6heterocyclyl-Ra, C(═O)NH2, C(═O)NHC5-6heterocyclyl-Ra, C(═O)N(C5-6heterocyclyl)2-Ra, SO2C5-6heterocyclyl-Ra, SO2NHC5-6heterocyclyl-Ra, SO2N(C5-6heterocyclyl)2-Ra, NH(C5-6heterocyclyl)-Ra, N(C5-6heterocyclyl)2-Ra, NHC(═O)C5-6heterocyclyl, and NC(═O)(C5-6heterocyclyl)2;
• R3 is independently selected from H, halogen, CN, NH2, OH, C1-6alkyl-Ra, C2-6alkenyl-Ra, C2-6alkynyl-Ra, C5-6cycloalkenyl-Ra, C3-12cycloalkyl-Ra, C1-6alkyl-C3-12cycloalkyl-Ra, C5-10aryl-Ra, C1-6alkyl-C5-10aryl-Ra, C5-10heterocyclyl-Ra, C1-6alkyl-C5-10heterocyclyl-Ra, C(═O)C5-6heterocyclyl-Ra, C(═O)C5-10aryl-Ra, C(═O)C3-12cycloalkyl-Ra, OC1-6alkyl-Ra, O—C5-10aryl-Ra, O—C5-6heterocyclyl-Ra, O—C3-12cycloalkyl-Ra, C(═O)OC1-6alkyl-Ra, C(═O)NH2, C(═O)NHC1-6alkyl-Ra, C(═O)N(C1-6alkyl)2-Ra, SO2C1-6alky l-Ra, SO2NHC1-6alkyl-Ra, SO2N(C1-6alkyl)2-Ra, NH(C1-6alkyl)-Ra, N(C1-6alkyl)2-Ra, NHC(═O)C1-6alkyl, NC(═O)(C1-6alkyl)2, NHC(═O)NHC1-6alkyl, NHC(═O)OC1-6alkyl, C5-6aryl-Ra, OC5-6aryl-Ra, C(═O)C5-6aryl-Ra, C(═O)OC5-6aryl-Ra, C(═O)NH2, C(═O)NHNH2, C(═O)NHC5-6aryl-Ra, C(═O)N(C5-6aryl)2-Ra, SO2C5-6aryl-Ra, SO2NHC5-6aryl-Ra, SO2N(C5-6aryl)2-Ra, NH(C5-6aryl)-Ra, N(C5-6aryl)2-Ra, NHC(═O)C5-6aryl, NC(═O)(C5-6aryl)2, NHC(═O)NHC5-6aryl, NHC(═O)OC5-6aryl, C5-6heterocyclyl-Ra, OC5-6heterocyclyl-Ra, C(═O)C5-6heterocyclyl-Ra, C(═O)OC5-6heterocyclyl-Ra, C(═O)NH2, C(═O)NHC5-6heterocyclyl-Ra, C(═O)N(C5-6heterocyclyl)2-Ra, SO2C5-6heterocyclyl-Ra, SO2NHC5-6heterocyclyl-Ra, SO2N(C5-6heterocyclyl)2-Ra, NH(C5-6heterocyclyl)-Ra, N(C5-6heterocyclyl)2-Ra, NHC(═O)C5-6heterocyclyl, NC(═O)(C5-6heterocyclyl)2, NHC(═O)NHC5-6heterocyclyl, and NHC(═O)OC5-6heterocyclyl;
• R4 is independently selected from H, OH, halogen, N(C1-4alkyl )2, NHC1-4alkyl, NH2, optionally substituted C1-6alkyl, optionally substituted OC1-6alkyl, optionally substituted C2-6alkenyl, optionally substituted C2-6alkynyl, optionally substituted C3-12cycloalkyl, optionally substituted C5-10aryl, optionally substituted C1-6alkyl-C5-10aryl, optionally substituted C5-10heterocyclyl and optionally substituted C1-6alkyl-C5-10heterocyclyl wherein such substituents is/are independently selected from:
• halogen, CN, NH2, OH, C1-6alkyl-Ra, OC1-6alkyl-Ra, C(═O)C1-6alkyl-Ra, C(═O)OC1-6alkyl-Ra, C(═O)NH2, C(═O)NHC1-6alkyl-Ra, C(═O)N(C1-6alkyl-Ra)2, SO2C1-6alkyl-Ra, SO2NHC1-6alkyl-Ra, SO2N(C1-6alkyl-Ra)2, NH(C1-6alkyl)-Ra, N(C1-6alkyl-Ra)2, NHC(═O)C1-6alkyl, NHC(═O)C1-6alkyl-Ra, NC(═O)(C1-6alkyl)2, C5-6aryl-Ra, OC5-6aryl-Ra, C(═O)C5-6aryl-Ra, C(═O)OC5-6aryl-Ra, C(═O)NH2, C(═O)NHC5-6aryl-Ra, C(═O)N(C5-6aryl-Ra)2, SO2C5-6aryl-Ra, SO2NHC5-6aryl-Ra, SO2N(C5-6aryl-Ra)2, NH(C5-6aryl)-Ra, N(C5-6aryl-Ra)2, NHC(═O)C5-6aryl, NC(═O)(C5-6aryl)2, C5-6heterocyclyl-Ra, OC5-6heterocyclyl-Ra, C(═O)C5-6heterocyclyl-Ra, C(═O)OC5-6heterocyclyl-Ra, C(═O)NH2, C(═O)NHC5-6heterocyclyl-Ra, C(═O)N(C5-6heterocyclyl-Ra)2, SO2C5-6heterocyclyl-Ra, SO2NHC5-6heterocyclyl-Ra, SO2N(C5-6heterocyclyl)2-Ra, NH(C5-6heterocyclyl)-Ra, N(C5-6heterocyclyl-Ra)2, NHC(═O)C5-6heterocyclyl, and NC(═O)(C5-6heterocyclyl)2.

A compound of formula (I) selected from:

• N˜3˜-(1-naphthylmethyl)pyridine-2,3-diamine;
• 6-[2-(1H-indol-6-yl)ethyl]pyridin-2-amine;
• 6-[2-(2-naphthyl)ethyl]pyridin-2-amine;
• 6-[2-(3-chloro-1H-indol-6-yl)ethyl]pyridin-2-amine;
• N˜3˜-(2-naphthylmethyl)pyridine-2,3-diamine;
• N˜3˜-(1,1′-biphenyl-4-ylmethyl)pyridine-2,3-diamine;
• N˜3˜-(1,1′-biphenyl-3-ylmethyl)pyridine-2,3-diamine;
• 6-[2-(3,8-dimethoxy-2-naphthyl)ethyl]pyridin-2-amine;
• N˜3˜-benzyl-6-phenoxypyridine-2,3-diamine;
• N˜3˜-[(3,8-dimethoxy-2-naphthyl)methyl]pyridine-2,3-diamine;
• N˜3˜-(3-pyridin-3-ylbenzyl)pyridine-2,3-diamine;
• 6-[2-(3-pyridin-3-ylphenyl)ethyl]pyridin-2-amine;
• N˜3˜-(1-biphenylen-2-ylethyl)pyridine-2,3-diamine;
• N˜3˜-[3-(benzyloxy)benzyl]pyridine-2,3-diamine;
• N˜3˜-(1,1′-biphenyl-3-ylmethyl)-6-methylpyridine-2,3-diamine;
• N˜3˜-(2-phenylethyl)pyridine-2,3-diamine;
• 6-methyl-N˜3˜-(3-pyridin-3-ylbenzyl)pyridine-2,3-diamine;
• N˜3˜-{[4′-(3-methyl-1H-pyrazol-5-yl)-1,1′-biphenyl-3-yl]methyl}pyridine-2,3-diamine;
• N˜3˜-[3-(1H-indol-6-yl)benzyl]pyridine-2,3-diamine;
• ethyl 3′-{[(2-aminopyridin-3-yl)amino]methyl}-1,1′-biphenyl-3-carboxylate;
• (3′-{[(2-aminopyridin-3-yl)amino]methyl}-1,1′-biphenyl-3-yl)acetonitrile;
• N˜3˜-(1H-indol-6-ylmethyl)-6-methylpyridine-2,3-diamine;
• N˜3˜-{3-[5-(1H-pyrazol-5-yl)thien-2-yl]benzyl}pyridine-2,3-diamine;
• N˜3˜-(4-methoxy-2,3-dimethylbenzyl)pyridine-2,3-diamine;
• 2-(3′-{[(2-aminopyridin-3-yl)amino]methyl}-1,1′-biphenyl-3-yl)ethanol;
• (3′-{[(2-aminopyridin-3-yl)amino]methyl}-1,1′-biphenyl-3-yl)methanol;
• N˜3˜-{[5-(4-fluorophenyl)pyridin-3-yl]methyl}-6-methylpyridine-2,3-diamine;
• N˜3˜-(3-butoxybenzyl)pyridine-2,3-diamine;
• N˜3˜-(5-bromo-2-ethoxybenzyl)pyridine-2,3-diamine;
• N˜3˜-[3-(cyclopentyloxy)benzyl]pyridine-2,3-diamine;
• N˜3˜-[(9-ethyl-9H-carbazo1-3-yl)methyl]pyridine-2,3-diamine;
• N˜3˜-[3-(1H-indol-6-yl)benzyl]-6-methylpyridine-2,3-diamine;
• N˜3˜-(5-bromo-2-methoxybenzyl)-6-methylpyridine-2,3-diamine;
• 6-methyl-N˜3˜-[(3-phenyl-1,3-dihydro-2, 1-benzisoxazol-5-yl)methyl]pyridine-2,3-diamine;
• N˜3˜-[5-(1H-indol-6-yl)-2-methoxybenzyl]-6-methylpyridine-2,3-diamine;
• N˜3˜-[2-(alkyloxy)-5-bromobenzyl]pyridine-2,3-diamine;
• N˜3˜-[2-(benzyloxy)-5-bromobenzyl]pyridine-2,3-diamine;
• N˜3˜-[5-bromo-2-(prop-2-ynyloxy)benzyl]pyridine-2,3-diamine;
• (3′-{[(2-amino-6-methylpyridin-3-yl)amino]methyl}-4′-methoxy-1,1′-biphenyl-3-yl)acetonitrile;
• N˜3˜-[(3′-amino-4-methoxy-1,1′-biphenyl-3-yl)methyl]-6-methylpyridine-2,3-diamine;
• N-(3′-{[(2-amino-6-methylpyridin-3-yl)amino]methyl}-4′-methoxy-1,1′-biphenyl-3-yl)acetamide;
• N˜3˜-(5-isoquinolin-4-yl-2-methoxybenzyl)-6-methylpyridine-2,3-diamine;
• 6-{2-[3-(1H-indol-6-yl)phenyl]ethyl}pyridin-2-amine;
• N˜3˜-(3-isoquinolin-4-ylbenzyl)-6-methylpyridine-2,3-diamine;
• N˜3˜-[(3′-amino-1,1′-biphenyl-3-yl)methyl]-6-methylpyridine-2,3-diamine;
• N˜3˜-[2-(benzyloxy)-5-(1H-indol-6-yl)benzyl]pyridine-2,3-diamine;
• 5-bromo-N˜3˜-[3-(1H-indol-6-yl)benzyl]pyridine-2,3-diamine;
• N˜3˜-[(3′,4-dimethoxy-1,1′-biphenyl-3-yl)methyl]-6-methylpyridine-2,3-diamine;
• N˜3˜-[5-bromo-2-(pyridin-2-ylmethoxy)benzyl]pyridine-2,3-diamine;
• N˜3˜-[(3′-methoxy-1,1′-biphenyl-3-yl)methyl]-6-methylpyridine-2,3-diamine;
• N˜3˜-[5-(1H-indol-6-yl)-2-(pyridin-2-ylmethoxy)benzyl]pyridine-2,3-diamine;
• N˜3-˜[2-(benzyloxy)-5-pyridin-3-ylbenzyl]pyridine-2,3-diamine;
• 5-bromo-N˜3˜-[(3′-methoxy-1,1′-biphenyl-3-yl)methyl]pyridine-2,3-diamine;
• 3-{[(2-aminopyridin-3-yl)amino]methyl}-3′-methoxy-1,1′-biphenyl-4-ol;
• N˜3˜-[3-(2-furyl)benzyl]-6-methylpyridine-2,3-diamine;
• N˜3˜-[5-(2-furyl)-2-methoxybenzyl]-6-methylpyridine-2,3-diamine;
• N˜3˜-[2-(benzyloxy)-5-tert-butylbenzyl]pyridine-2,3-diamine;
• N˜3˜-{[3′-methoxy-4-(pyridin-2-ylmethoxy)-1,1′-biphenyl-3-yl]methyl}pyridine-2,3-diamine;
• 6-chloro-N˜3˜-[(3′-methoxy-1,1′-biphenyl-3-yl)methyl]pyridine-2,3-diamine;
• 5-chloro-N˜3˜-[(3′-methoxy-1,1′-biphenyl-3-yl)methyl]pyridine-2,3-diamine;
• N˜3˜-{[4-(benzyloxy)-3′-methoxy-1,1′-biphenyl-3-yl]methyl}pyridine-2,3-diamine;
• N˜3˜-[5-bromo-2-(pyridin-3-ylmethoxy)benzyl]pyridine-2,3-diamine;
• N˜3˜-[5-(1H-indol-6-yl)-2-(pyridin-3-ylmethoxy)benzyl]pyridine-2,3-diamine;
• N˜3˜-[5-(1H-indol-6-yl)-2-(pyridin-4-ylmethoxy)benzyl]pyridine-2,3-diamine;
• N˜3˜-[3-(6-chloropyridin-3-yl)benzyl]pyridine-2,3-diamine;
• N˜3˜-[(3′,4′-dimethoxy-1,1′-biphenyl-3-yl)methyl]pyridine-2,3-diamine;
• 5-chloro-N˜3˜-(3-pyridin-3-ylbenzyl)pyridine-2,3-diamine;
• N˜3˜-[3-(5-methoxypyridin-3-yl)benzyl]pyridine-2,3-diamine;
• 2-[2-(6-aminopyridin-2-yl)ethyl]-4-(1H-indol-6-yl)phenol;
• 6-{2-[5-(1H-indol-6-yl)-2-(pyridin-2-ylmethoxy)phenyl]ethyl}pyridin-2-amine;
• N˜3˜-[3-(2-furyl)benzyl]pyridine-2,3-diamine;
• N˜3˜-[2-[2-(dimethylamino)ethoxy]-5-(1H-indol-6-yl)benzyl]pyridine-2,3-diamine;
• N˜3˜-[5-pyridin-3-yl-2-(2-pyrrolidin-1-ylethoxy)benzyl]pyridine-2,3-diamine;
• N˜3˜-[5-(1H-indol-6-yl)-2-(2-pyrrolidin-1-ylethoxy)benzyl]pyridine-2,3-diamine;
• N˜3˜-(3-pyrimidin-5-ylbenzyl)pyridine-2,3-diamine;
• N˜3˜-(5-bromo-2-isobutoxybenzyl)pyridine-2,3-diamine;
• 6-{2-[3-(5-methoxypyridin-3-yl)phenyl]ethyl}pyridin-2-amine;
• 6-[2-(3′-methoxy-1,1′-biphenyl-3-yl)ethyl]pyridin-2-amine;
• 6-{2-[3-(2-furyl)phenyl]ethyl}pyridin-2-amine;
• N˜3˜-[3-(2-methyl-1,3-benzothiazol-5-yl)benzyl]pyridine-2,3-diamine;
• N˜3˜-[3-(6-methoxypyridin-3-yl)benzyl]pyridine-2,3-diamine;
• N˜3˜-[(3′-amino-1,1′-biphenyl-3-yl)methyl]pyridine-2,3-diamine;
• 6-[2-(3′,4′-dimethoxy-1,1′-biphenyl-3-yl)ethyl]pyridin-2-amine;
• N˜3˜-(3-bromobenzyl)-6-(morpholin-4-ylcarbonyl)pyridine-2,3-diamine;
• N-(3′-{[(2-aminopyridin-3-yl)amino]methyl}-1,1′-biphenyl-3-yl)propanamide;
• N-(3′-{[(2-aminopyridin-3-yl)amino]methyl}-1,1′-biphenyl-3-yl)butanamide;
• methyl 3-[(3′-{[(2-aminopyridin-3-yl)amino]methyl}-1,1′-biphenyl-3-yl)amino]-3-oxopropanoate;
• 2-[(3′-{[(2-aminopyridin-3-yl)amino]methyl}-1,1′-biphenyl-3-yl)amino]-2-oxoethyl acetate;
• N-(3′-{[(2-aminopyridin-3-yl)amino]methyl}-1,1′-biphenyl-3-yl)-2-(2-methoxyethoxy)acetamide;
• N˜3˜-[3-(5-propoxypyridin-3-yl)benzyl]pyridine-2,3-diamine;
• {6-amino-5-[(3-bromobenzyl)amino]pyridin-2-yl}methanol;
• {6-amino-5-[(3-pyridin-3-ylbenzyl)amino]pyridin-2-yl} methanol;
• 2-amino-6-[2-(3′-methoxy-1,1′-biphenyl-3-yl)ethyl]nicotinonitrile;
• 6-(2-Biphenyl-3-yl-ethyl)-3-methyl-pyridin-2-ylamine;
• 6-[2-(3′-methoxy-biphenyl-3-yl)-ethyl]-3-methylpyridin-2-ylamine;
• 6-(2-biphenyl-3-ylethyl)-5-fluoro-pyridin-2-ylamine;
• 5-fluoro-6-[2-(3′-methoxy-biphenyl-3-yl)-ethyl]-pyridin-2-ylamine.