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AssigneesThe Regents of the University of Colorado, a body corporate, University of Alberta
InventorsRobert S. Hodges, Randall T. Irvin, Carmen Giltner, Erin Van Schaik
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The present invention relates to a composition and method for preventing or inhibiting biofilm formation on biotic or abiotic surfaces. The composition comprises a peptide based on the C-terminal receptor binding domain of Pseudomonas aeruginosa type IV pilin, which binds to an abiotic surface (e.g., steel, plastic) with high affinity and prevents binding of a variety of P. aeruginosa strains to the surface. The inventive composition represents a non-toxic inhibitor for biofilm formation, particularly on an abiotic surface, which is responsible for a large number of problematic diseases and massive economic losses. The inventive method is useful as a safe and environmentally friendly means of modifying a surface of a variety of biomedical, nanotechnological, and biotechnological devices or articles.
A composition for preventing or inhibiting biofilm formation on a surface comprising one or more peptide having a general core amino acid sequence derived from the C-terminal receptor binding domain of Pseudomonas type IV pilin and optionally a carrier agent.
A peptide useful for preventing or inhibiting biofilm formation on a surface wherein the peptide comprises a general core amino acid sequence derived from the C-terminal receptor binding domain of Pseudomonas type IV pilin.
Dependencies are inferred from the claim text.