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US 2008/0287352 A1Published application
Anti-Histone H1 Monoclonal Antibody and Hybridoma for the Production Thereof
AssigneeAmateraspharma Inc.
InventorsTakeshi Goto, Shuji Sato, Kazuhisa Ono, Seiko Shigeta, Seiji Kawamoto, Shigeru Goto
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Abstract
The present invention discloses anti-histone H1 monoclonal antibodies, hybridomas for the production thereof, and polypeptides, which are useful for suppressing, predicting, or diagnosing transplant rejection in organ transplantation.
Claims12
1-32. (canceled)
A polypeptide which binds specifically to anti-histone H1 antibody wherein said polypeptide is selected from a group consisting of the polypeptides given in the following (a), (b), (c), and (d):
- (a) a polypeptide consisting of an amino acid sequence represented by SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, or SEQ ID NO:
- 8;
- (b) a polypeptide consisting of an amino acid sequence which includes substitutions, deletions, or additions of one or several amino acids in an amino acid sequence represented by SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, or SEQ ID NO:
- 8;
- (c) a polypeptide consisting of a partial sequence of an amino acid sequence represented by SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, or SEQ ID NO:
- 8;
- (d) a polypeptide comprising an amino acid sequence represented by SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, or SEQ ID NO:
- 8, or a partial sequence thereof.
21 more elements
Dependencies are inferred from the claim text.