Nasal administration of benzodiazepines
AssigneeQuestcor Pharmaceuticals, Inc.
InventorsSteve Cartt, David Medeiros
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Abstract
Particulate formulations of benzodiazepines, such as diazepam, are used for nasal administration of diazepine drugs to patients. Multimodal particulate formulations of benzodiazepines and methods for their use, e.g. by nasal administration for the treatment of seizure, are also provided.
Claims31
A composition for nasal administration of a medicament comprising a first population of particles having a first effective average particle size and a second population of particles having a second effective average particle size, wherein the first effective average particle size is at least 1.5 times that of the second effective average particle size.
A pharmaceutical particulate composition for nasal delivery of a medicament comprising particulates having a multimodal particle size distribution.
An aerosol composition of an aqueous suspension or dispersion of nanoparticulate benzodiazepine particles, wherein:
- the droplets of the aerosol have a mass median aerodynamic diameter (MMAD) less than or equal to about 1000 μm and the nanoparticulate benzodiazepine particles have an effective average particle size of less than about 5000 nm.
A method of administering a benzodiazepine drug to a patient, comprising administering to the nose or nasal cavity an effective amount of an aerosol composition of an aqueous suspension or dispersion of nanoparticulate benzodiazepine particles, wherein:
- the droplets of the aerosol have a mass median aerodynamic diameter (MMAD)less than or equal to about 1000 μm and the nanoparticulate benzodiazepine particles have an effective average particle size of less than about 5000 nm.
A pharmaceutical composition for nasal administration of benzodiazepine comprising benzodiazepine particles and one or more surface active agents adsorbed to a surface thereof.
A method of administering a benzodiazepine drug to a patient, comprising administering to the patient's nose or nasal cavity a pharmaceutical composition comprising particles of a benzodiazepine drug having a surface active agent adsorbed to a surface thereof.
Dependencies are inferred from the claim text.