Compositions and Method for Brain Specific Targeted Delivery of Therapeutic Agents
OwnerRichard P. Kraig, Michael Kaminskiinventors
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Abstract
Disclosed are methods and compositions for delivering a therapeutic agent to target organs or tissues, such as brain. The methods and compositions use bone marrow stem cells, monocytes, macrophages or microglial cells to deliver the therapeutic agent associated with nanoparticles to the target organ or tissue.
Claims31
A method of delivering a therapeutic agent to the brain of a mammal comprising:
- (a) contacting a bone marrow stem cell, monocyte, macrophage, or microglia ex vivo with a nanoparticle comprising the therapeutic agent under conditions that allow endocytosis of the nanoparticle by the cell;
- (b) delivering the cell of step (a) to the brain.
A method of producing a bone marrow stem cell, monocyte, macrophage or microglial cell for delivering a therapeutic agent to a tissue comprising:
- (a) contacting the cell ex vivo with a nanoparticle comprising the therapeutic agent comprising a polynucleotide under conditions that allow endocytosis of the nanoparticle by the cell.
A composition for delivering a therapeutic agent to a tissue, comprising a bone marrow stem cell, monocyte, macrophage or microglial cell comprising a nanoparticle comprising the therapeutic agent, and a medium substantially free of serum or protein.
A composition for delivering a therapeutic agent to a tissue, the composition comprising a bone marrow stem cell, monocyte, macrophage or microglial cell comprising a nanoparticle comprising the therapeutic agent, wherein the therapeutic agent comprises a polynucleotide.
Dependencies are inferred from the claim text.