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US 2008/0269481 A1Published application
Compounds and methods for the treatment or prevention of Flavivirus infections
AssigneeVertex Pharmaceuticals (Canada) Incorporated
InventorsLaval Chan Chun Kong, Sanjoy Kumar Das, Nghe Nguyen-Ba, Liliane Halab, Bettina Hamelin, Oswy Z. Pereira, Carl Poisson, Melaine Proulx, Thumkunta Jagadeeswar Reddy, Zhang Ming-Qiang
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Abstract
Compounds represented by formula: wherein X, Y and Z are as defined herein, pharmaceutically acceptable salts thereof, and related compounds, are suitable for use in treating or preventing a Flaviviridae viral infection in a host.
Claims2
1-49. (canceled)
A compound of the formula:
- or a pharmaceutically acceptable salt thereof;
- wherein;
- Z is cyclohexyl substituted by one or more substituents independently chosen from halogen, SO2Rf, CONRgRh, C1-6 alkyl, C6-12 aralkyl, C6-12 aryl, C1-6 alkyloxy, C(O)C1-6 alkyl, C3-10 heterocycle, hydroxyl, NRgRh, C(O)ORf or cyano;
- Rf, Rg and Rh in each case are independently H or C1-6 alkyl;
- Y is unsubstituted phenyl or phenyl substituted by one or more substituents independently chosen from halogen, nitro, SO2Rf, C1-6 alkyl, C1-6 alkyloxy, C(O)C1-6 alkyl, C(O)ORf, cyano and azido;
- X is cyclohexyl unsubstituted or substituted by one or more substituents independently chosen from C1-6 alkyl, halogen, C2-6 alkenyl, C2-6 alkynyl or C1-6 alkyloxy;
- and
- m is 0.
5 more elements
Dependencies are inferred from the claim text.