Antimicrobial Polymers
AssigneeEthicon, Inc.
InventorsRobert Engel, JaimeLee I. Rizzo, Karin Melkonian, Paul Watt
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Abstract
The present invention is concerned with providing antimicrobial compounds and processes for the production thereof. More particularly, the present invention provides antimicrobial polymeric materials comprising a polymer linked to a positively charged moiety via a carboxyl group. The present invention also provides processes for the production of such antimicrobial compounds and uses therefor.
Claims39
An antimicrobial polymeric compound having formula (1):
- P—(X)n (1)
- P comprises a polymer linked to X via a carboxyl group;
- X comprises a group —(R—Vm+—R1—R2) q(Yp−);
- n is an integer of 1-1×107;
- R is independently selected from divalent hydrocarbon radicals;
- V comprises a positively charged moiety;
- m represents an integer;
- R1 is independently selected from divalent hydrocarbon radicals;
- R2 is independently selected from the group consisting of —H, —SH, —F, —Cl, —Br, —I, —OR3, —HN(O)CR4, or —O(O)CR5, wherein R3, R4 and R5 are independently selected from the group consisting of —H and monovalent hydrocarbon radicals;
- Y represents an anion;
- q represents m/p;
- and,
- p represents an integer;
- or a pharmaceutically acceptable derivative of a compound of formula (1).
A process for the preparation of a compound having formula (1), comprising reacting a compound having the formula (2):
- P—{[COO−]f(Zg+)}n (2)
- wherein:
- P is as defined in any preceding claim;
- n is as defined in any preceding claim;
- Z is a cation;
- f represents 1/g;
- and
- g represents 1, 2, 3, 4, 5 or 6;
- with a group having the formula (3)
- L-X (3)
- wherein X is as defined in any preceding claim;
- and,
- L is a leaving group.
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Dependencies are inferred from the claim text.