Chemical Compounds

A compound according to formula (I):

• wherein:
• X is O, S, S(O), S(O)2, —N(Rf), or —OC(O)O;
• R1 is H, optionally substituted C1-C8 alkyl, C1-C6 haloalkyl, optionally substituted heterocycloalkyl, optionally substituted —C1-C3 alkylene-heterocycloalkyl, optionally substituted phenyl, optionally substituted —C1-C3 alkylene-phenyl, optionally substituted naphthyl, optionally substituted —C1-C3 alkylene-naphthyl, optionally substituted heteroaryl, or optionally substituted —C1-C3 alkylene-heteroaryl,
• where said C1-C8 alkyl is optionally substituted with one substituent selected from the group consisting of:
• cyano, —NRfRf, —C(O)NRfRf, C3-C6 cycloalkyl, and C1-C6 alkoxy optionally substituted with one phenyl group;
• where said heterocycloalkyl and —C1-C3 alkylene-heterocycloalkyl are optionally substituted with one to three substituents each independently selected from the group consisting of:
• halo, hydroxyl, oxo, and C1-C6 alkyl;
• where said phenyl, —C1-C3 alkylene-phenyl, heteroaryl, and —C1-C3 alkylene-heteroaryl, are each optionally substituted with one to three substituents each independently selected from the group consisting of:
• halo, —CN, —N(Rb)SO2Re, —N(Rb)C(O)Ra, —C(O)NRaRb, —C(O)H, —SO2Ri, —NRaRb, —SO2NRaRb, —ORc, —N(Rb)C(O)NRaRb, —N(Rb)C(O)ORd, —C(O)ORa, C1-C6 alkyl, C1-C6 alkyl substituted with one to three substituents independently selected from the group consisting of:
• —NRaRb, C3-C6 cycloalkyl, phenyl, —ORc, heterocycloalkyl, and heterocycloalkyl substituted with OH, —C(O)NH2, or one or two C1-C6 alkyl groups;
• C1-C6 haloalkyl, C1-C6 haloalkyl substituted with one to three substituents each independently selected from the group consisting of —NRaRb, C3-C6 cycloalkyl, phenyl, heterocycloalkyl, and heterocycloalkyl substituted with one or two C1-C6 alkyl groups;
• heterocycloalkyl and heterocycloalkyl substituted with one or two C1-C6 alkyl groups;
• R2 is optionally substituted C1-C6 alkyl, optionally substituted aryl, optionally substituted C3-C6 cycloalkyl, optionally substituted heteroaryl, or optionally substituted heterocycloalkyl,
• wherein said C1-C6 alkyl is optionally substituted with one to three substituents each independently selected from the group consisting of:
• halo, —OR1, —NRgRh, —NHC(O)Rg, and Rj;
• and where said aryl and heteroaryl are optionally substituted with one to three substituents each independently selected from the following:
• halo, —ORg, nitro, cyano, CF3, C1-C6 alkyl, C(O)R9, COORg, —NRgRh, —NHC(O)Rg, —C(O)NRgRh, —S(O)2Rg, —NHS(O)2Rg, and —S(O)2NRgRh;
• and where said C3-C6 cycloalkyl and heterocycloalkyl are optionally substituted by one to three substituents each independently selected from the group consisting of:
• —OH, oxo, C1-C6 alkyl, and C1-C6 haloalkyl;
• R3 is one to three substituents each independently selected from the group consisting of:
• OH, oxo, C1-C6 alkyl, and C1-C6 haloalkyl;
• each Ra is independently selected from the group consisting of:
• H, optionally substituted C1-C3 alkyl, optionally substituted phenyl, optionally substituted heteroaryl, optionally substituted C3-C7 cycloalkyl, and optionally substituted heterocycloalkyl, where said C1-C3alkyl is optionally substituted with one to three substituents each independently selected from the group consisting of:
• halo, ORc, C1-C6 haloalkyl, phenyl, and heteroaryl;
• and where said phenyl, heteroaryl, C3-C7 cycloalkyl, and heterocycloalkyl are optionally substituted with one to three substituents each independently selected from the group consisting of:
• halo, ORc, C1-C6 alkyl, and C1-C6 haloalkyl;
• each Rb is independently selected from the group consisting of:
• H and optionally substituted C1-C3 alkyl, where said C1-C3 alkyl is optionally substituted with one to three ORc groups;
• each Rc is independently selected from the group consisting of:
• H, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 haloalkyl, optionally substituted C3-C7 cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl, where said C1-C6 alkyl and C1-C6 haloalkyl are optionally substituted with one to three substituents each independently selected from the group consisting of:
• C3-C6 cycloalkyl, phenyl, heterocycloalkyl, and heteroaryl;
• and where said aryl and heteroaryl are optionally substituted with one to three substituents each independently selected from the group consisting of:
• halo, C1-C3 alkyl, C1-C3 haloalkyl and OH;
• and where said C3-C7 cycloalkyl and heterocycloalkyl are optionally substituted with one to three C1-C3 alkyl groups;
• each Rd is independently optionally substituted C1-C3 alkyl, where said C1-C3 alkyl is optionally substituted with one to three substituents each independently selected from the group consisting of:
• C3-C6 cycloalkyl;
• phenyl optionally substituted with one to three substituents each independently selected from the group consisting of:
• halo, C1-C6 alkyl, and C3-C6 cycloalkyl;
• and heteroaryl optionally substituted with one to three substituents each independently selected from the group consisting of:
• halo, C1-C6 alkyl, and C3-C6 cycloalkyl;
• each Re is independently selected from the group consisting of:
• optionally substituted C1-C6 alkyl, optionally substituted phenyl, optionally substituted heteroaryl, optionally substituted C5-C7 cycloalkyl, and optionally substituted heterocycloalkyl, where said C1-C6 alkyl is optionally substituted with one substituent selected from the group consisting of:
• ORc, trifluoromethyl, phenyl, heteroaryl, heterocycloalkyl optionally substituted with ORc or heterocycloalkyl, and NRaRb;
• where said phenyl and heteroaryl are optionally substituted with one to three substituents each independently selected from the group consisting of:
• halo, CN, C1-C6 alkyl, C1-C6 haloalkyl, N(Rb)C(O)Ra, and ORf;
• and where said C5-C7 cycloalkyl and heterocycloalkyl are optionally substituted with one to three substituents each independently selected from the group consisting of:
• halo, C1-C6 alkyl optionally substituted with ORc and C3-C6 cycloalkyl;
• each Rf is independently selected from the group consisting of:
• H and C1-C6 alkyl;
• each Rg is independently selected from the group consisting of:
• H, C1-C6 alkyl, C3-C6 cycloalkyl, heteroaryl, and phenyl;
• each Rh is independently selected from the group consisting of:
• H and C1-C6 alkyl optionally substituted with one phenyl group;
• each Ri is independently selected from the group consisting of:
• H, C1-C6 alkyl, C1-C6 haloalkyl, and phenyl;
• and
• Rj is optionally substituted aryl, optionally substituted heteroaryl, optionally substituted C3-C6 cycloalkyl, or optionally substituted heterocycloalkyl,
• where said aryl and heteroaryl are optionally substituted with one to three substituents each independently selected from the group consisting of:
• —ORf, nitro, cyano, CF3, C1-C6 alkyl, C(O)Rf, COORf, —NRfRg, —NHC(O)Rf, —C(O)NRfRg, —S(O)2Rf, —NHS(O)2Rf, and —S(O)2NRfRg;
• and where said C3-C6 cycloalkyl and heterocycloalkyl are optionally substituted with one to three substituents each independently selected from the group consisting of:
• —OH, oxo, C1-C6 alkyl, and C1-C6 haloalkyl;
• or a pharmaceutically acceptable salt thereof.