Azepane- or Azocane-Substituted Pyrazoline Derivatives, Their Preparation and Use as Medicaments

Azepane- or Azocane substituted pyrazoline compounds of general formula I,

• wherein
• Z is selected from C1-4-Alkyl, substituted or unsubstituted, branched or linear, saturated or unsaturated;
• X and Y independently represent phenyl, thienyl, naphtyl or pyridyl which groups may be substituted with 1, 2 or 3 substituents W, which can be the same or different, selected from the group
• branched or linear C1-3-alkyl or branched or linear C1-3-alkoxy, phenyl, hydroxy, chloro, bromo, fluoro, iodo, SH, trifluoromethyl, CHF2, CH2F, OCHF2, trifluoromethylthio, trifluoromethoxy, methylsulfonyl, carboxyl, trifluoromethylsulfonyl, cyano, carbamoyl, sulfamoyl and acetyl;
• O—P, with P denominating a prodrug group consisting of aryl, C8-20-alkyl, heteroaryl, C(O)-aryl, C(O)-heteroaryl, C(O)—C1-20-alkyl;
• R8 representing a hydrogen atom or a branched or linear C1-3-alkyl group, while R9 is representing
• with R5, R6 and R7 being independently from one another selected from H, F, Cl, Br, I, OH, SH, C1-4alkyl, C1-4alkoxy, CF3, CHF2, CH2F, OCF3, a keto-group, NO2 or NH2;
• and n being 1 or 2;
• or
• R8 and R9 together with the connecting Nitrogen atom are representing
• with R5, R6 and R7 being independently from one another selected from H, F, Cl, Br, I, OH, SH, C1-4alkyl, C1-4alkoxy, CF3, CHF2, CH2F, OCF3, a keto-group, NO2 or NH2;
• and n being 1 or 2;
• optionally in the form of its racemate, pure stereoisomers, especially enantiomers or diastereomers or in the form of mixtures of stereoisomers, especially enantiomers or diastereomers, in any suitable ratio;
• in the form shown or in form of the acid or base or in form of a salt, especially a physiologically acceptable salt, or in form of a solvate, especially a hydrate or in form of a corresponding N-oxide thereof.