Endogenous thiadiazabicyclo glutathione-adduct
OwnerIan BLAIR, Clementina Mesaros +3inventors
InventorsIan BLAIR, Clementina Mesaros, Wenying Jian, Seon Hwa Lee, Tomoyuki Oe
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Abstract
This invention relates to mediators of apoptosis. Specifically, the invention relates to thiadiazabicyclo-4-oxo-2(E)-nonenal-Glutathione adduct as a novel agent for inducing apoptosis in cells depleted of GSH.
Claims24
A composition comprising Thiadiazabicyclo-4-oxo-2(E)-nonenal-Glutathione (TOG).
A method of inducing apoptosis in a cell comprising the step of contacting said cell with Thiadiazabicyclo-4-oxo-2(E)-nonenal-Glutathione (TOG), thereby inducing apoptosis in a cell.
The use of Thiadiazabicyclo-4-oxo-2(E)-nonenal-Glutathione (TOG) in a composition for the treatment of hypeproliferative disease in a subject in need thereof.
Dependencies are inferred from the claim text.