Separation And Manipulation Of A Chiral Object
AssigneeDynamic Connections, LLC
InventorsOsman Kibar, Mirianas Chachisvilis, Eugene Tu, Thomas H. Marsilje
Life of this patent
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Abstract
Among other things, to cause directional motion of chiral objects in a mixture in a chamber, a field is rotated relative, to a chamber to cause rotation of the chiral objects. The rotation of the objects causes them to move directionally based on their chirality.
Claims253
A method for use in directional motion of chiral objects in a mixture, the method comprising, within a chamber, applying a field across the chamber that is rotating relative to the chamber to cause rotation of the chiral objects, the rotation of the objects causing them to move directionally based on their chirality.
The method of claim in which the field strength and the speed of rotation of the field are selected to achieve a predetermined level of efficiency of the directional motion.
A method comprising
- enhancing a purity of at least one of two enantiomers in a mixture by separating molecules of the two enantiomers in each of a series of chambers, the purity of the enantiomer in at least some of the successive chambers being at increasingly higher levels, and
- transferring a portion of at least one of the separated enantiomers from each of the chambers to a previous one or a next one of the chambers in the series.
An apparatus comprising
- a chamber to hold a mixture containing one or more enantiomers,
- a field source to impose a rotating field on the mixture, and
- the chamber having an inlet to receive the mixture, and an outlet to remove a portion of the mixture that contains at least one of the enantiomers in an elevated concentration relative to its average concentration in the mixture in the chamber.
The apparatus of 203 in which the mixture is non-pure.
The apparatus of 203 in which the mixture is enantiopure.
The apparatus of 203 in which the chiral objects have only one stereocenter.
The apparatus of 203 in which the chiral objects have more than one stereocenter.
The apparatus of 203 in which the direction of the field is reversed for the same chiral objects to confirm the absolute configuration.
An enantiomerically enriched composition comprising an excess of (+)-5-[3,5-dimethylphenoxy)methyl]oxazolidin-2-one.
An enantiomerically enriched composition comprising an excess of (−)-5-[3,5-dimethylphenoxy)methyl]oxazolidin-2-one.
Dependencies are inferred from the claim text.