Implantable medical articles having pro-healing coatings
OwnerStuart K. Williams, David E. Babcock +2inventors
InventorsStuart K. Williams, David E. Babcock, Joseph A. Chinn, David L. Clapper
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Abstract
Coatings including adhesion factors for the surfaces of implantable medical articles are disclosed. The coatings are used to improve the function of the device by promoting a pro-healing response following implantation. The coatings can modulate endothelialization of the article surface to reduce the risk of adverse tissue responses that may reduce the functionality of the device.
Claims21
A coated intravascular medical device comprising:
- a body member comprising a metal or metal alloy and having a body member surface, and
- a coating on the body member surface comprising:
- a first layer that is in contact with tissue or body fluid, wherein the first layer comprises, predominantly, an adhesion factor and a photogroup;
- and
- a second layer located between the body member surface and the first layer, the second layer comprising a polymeric material, and wherein the photogroup bonds the adhesion factor to the polymeric material.
A coated intravascular medical device comprising:
- a body member having a body member surface, and
- a bioactive agent-releasing coating on the body member surface comprising:
- a first layer that is in contact with tissue or body fluid, wherein the first layer comprises, predominantly, a adhesion factor and a photogroup;
- and
- a second layer located between the body member surface and the first layer, the second layer comprising a polymeric material and a bioactive agent, and wherein the photogroup bonds the adhesion factor to the polymeric material.
A method for improving the endothelialization of a surface of an implantable medical article, the method comprising steps of
- providing a medical article with a coating comprising a polymeric material, a bioactive agent, an adhesion factor, and a photogroup that bonds the adhesion factor to the polymeric material;
- and
- implanting the coated medical article in a subject, wherein the coating promotes a level of endothelialization in the subject that is greater than a level of endothelialization observed without the adhesion factor and photogroup.
A method for modulating the endothelialization of a surface of an implantable medical article, the method comprising steps of
- obtaining information regarding the endothelialization of a surface of the medical article, wherein the medical article has a first level of endothelialization when implanted into a subject after a period of time, and the first level of endothelialization is associated with an undesirable tissue response;
- providing a medical article with a coating comprising at least one adhesion factor and a photogroup to form a coated medical article;
- and
- implanting the coated medical article in a subject, wherein the coating promotes a second level of endothelialization in the subject that is less than the first level of endothelialization after the period of time.
A coated intravascular medical device comprising a body member comprising a bioresorbable material, and a coating on the bioresorbable body member, the coating comprising adhesion factor and a photogroup, wherein the photogroup allows the adhesion factor to form a coated layer on the surface of the body member.
Dependencies are inferred from the claim text.