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US 2008/0227808 A1Published application
Substituted Phenylether-Thienopyridone Compounds With Antibacterial Activity
AssigneeReplidyne, Inc.
InventorsJOSEPH GUILES, XICHENG SUN, NEBOJSA JANJIC, SARAH STRONG
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Abstract
Novel bicyclic heteroaromatic compounds are provided that are inhibitors of bacterial methionyl tRNA synthetase (MetRS). Compounds of the invention generally have a left hand side phenylether constituent and a right hand side thienopyridone constituent. Also disclosed are methods for their preparation and their use in therapy as antibacterial agents, particularly as anti-Clostridium difficile agents.
Claims8
A compound of formula (I):
- in which:
- R1 is selected from the group consisting of aryl and heteroaryl groups, including but not limited to substituted and unsubstituted benzene, toluene, phenol, anisole, thiazole, thiazolidine and pyridine, alkenes, imines, and other like substituents;
- R2 is independently selected from halo, cyano, hydroxyl, (C1-6)alkyl (optionally substituted by halo, hydroxyl, amino, carboxy, or (C1-6) alkoxycarbonyl), (C1-6) cycloalkyl, (C1-6) alkoxy, amino, mono- or di-(C1-6)alkylamino, acylamino, carboxy, (C1-6)alkoxycarbonyl, carboxy(C1-6)alkyloxy, (C1-6)alkylthio, (C1-6)alkylsulphinyl, (C1-6)alkylsulphonyl, sulphamoyl, mono- and di-(C1-6)alkylsulphamoyl, carbamoyl, mono- and di-(C1-6)alkylcarbamoyl, and heteroxy;
- R3 is selected from a halo, (C1-3)alkyl, (C2-3)alkenyl, (C2-3)alkynyl or other like substituents;
- n is one, two or three;
- and
- m is 0 or an integer from 1 to 3.
4 more elements
Dependencies are inferred from the claim text.