Immortalized Avian Cell Lines For Virus Production
AssigneeProbiogen AG
InventorsVolker Sandig, Ingo Jordan
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Abstract
The present invention relates to immortalized avian cell lines suitable for production of biologicals or viruses for vaccination. In particular, the cell lines are derived from primary cells which are transformed with at least two viral or cellular genes, one of which causes cell cycle progression whereas the other interferes with innate protective mechanisms of the cell induced by dysregulated replication. The invention moreover relates to the production of said immortalized cell lines and their use for producing biologicals or viruses for vaccination.
Claims14
An avian cell line immortalized with a combination of viral and/or cellular genes (gene(s)), at least one first gene affecting the function of the retinoblastoma protein and at least one second gene affecting the p53 protein or a family member thereof.
Dependencies are inferred from the claim text.