Pharmaceutical compounds

A compound which is a fused pyrimidine of formula (I):

• wherein
• A represents a thiophene or furan ring;
• n is 1 or 2;
• R1 is a group of formula:
• wherein
• m is 0 or 1;
• R30 is H or C1-C6 alkyl;
• R4 and R5 form, together with the N atom to which they are attached, a 5- or 6-membered saturated N-containing heterocyclic group which includes 0 or 1 additional heteroatoms selected from N, S and O, which may be fused to a benzene ring and which is unsubstituted or substituted;
• or one of R4 and R5 is alkyl and the other is a 5- or 6-membered saturated N-containing heterocyclic group as defined above or an alkyl group which is substituted by a 5- or 6-membered saturated N-containing heterocyclic group as defined above;
• R2 is selected from:
• wherein R6 and R7 form, together with the nitrogen atom to which they are attached, a morpholine, thiomorpholine, piperidine, piperazine, oxazepane or thiazepane group which is unsubstituted or substituted;
• and
• wherein Y is a C2-C4 alkylene chain which contains, between constituent carbon atoms of the chain and/or at one or both ends of the chain, 1 or 2 heteroatoms selected from O, N and S, and which is unsubstituted or substituted;
• and R3 is selected from:
• (a) a group of the following formula:
• wherein B is a phenyl ring which is unsubstituted or substituted and Z is selected from H, —OR, —SR, CH2OR, —CO2R, CF2OH, CH(CF3)OH, C(CF3)2OH, —(CH2)qOR, —(CH2)qNR2—C(O)N(R)2, —NR2, —NRC(O)R, —S(O)mN(R)2, —OC(O)R, OC(O)N(R)2, —NRS(O)mR, —NRC(O)N(R)2, CN, halogen and —NO2, wherein each R is independently selected from H, C1-C6 alkyl, C3-C10 cycloalkyl and a 5- to 12-membered aryl or heteroaryl group, the group being unsubstituted or substituted, m is 1 or 2 and q is 0, 1 or 2;
• (b) a heteroaryl group which contains 1, 2, 3 or 4 ring nitrogen atoms and 0, 1 or 2 additional heteroatoms selected from O and S, which group is monocyclic or bicyclic and which is unsubstituted or substituted;
• and
• (c) a group comprising a benzene ring which is unsubstituted or substituted and which is fused to a heteroaryl group as defined above;
• or a pharmaceutically acceptable salt thereof;
• provided that R3 is not an indole group or an indazole group, which group is unsubstituted or substituted;
• or a pharmaceutically acceptable salt thereof.