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US 2008/0193416 A1Published application
Herpes Virus-Based Compositions and Methods of Use
AssigneeUniversity of Rochester
InventorsHoward J. Federoff, William J. Bowers
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Abstract
This disclosure features vectors, targeting vectors, modified artificial chromosomes, herpes virus particles in which such chromosomes are packaged, and methods of using the herpes virus particles to identify therapeutic agents and targets for therapeutic intervention.
Claims21
A targeting vector comprising a pair of cleavage sites that flank
- (a) a packaging/cleavage site of a herpes virus;
- (b) an origin of replication (ori) of a herpes virus;
- (c) an antibiotic resistance gene;
- and, optionally
- (d) a sequence that encodes a detectable marker.
2 more elements
A targeting vector comprising:
- (a) a packaging/cleavage site of a herpes virus;
- (b) an origin of replication (ori) of a herpes virus;
- (c) an antibiotic resistance gene;
- and, optionally
- (d) a sequence that encodes a detectable marker, wherein the packaging/cleavage site is flanked by a first pair of cleavage sites and the antibiotic resistance gene is flanked by a second pair of cleavage sites.
2 more elements
A modified artificial chromosome comprising
- (a) a pair of cleavage sites that flank
- (i) a packaging/cleavage site of a herpes virus;
- (ii) an ori of a herpes virus;
- (iii) a first antibiotic resistance gene;
- and, optionally
- (iv) a sequence that encodes a detectable marker;
- (b) a nucleic acid sequence of interest, and
- (c) a second antibiotic resistance gene.
5 more elements
21-106. (canceled)
Dependencies are inferred from the claim text.