# US 2008/0188669 A1 · Novel mixture and compounds from mycelia of Antrodia camphorata and use thereof

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- Number: US 2008/0188669 A1
- Document ID: US20080188669A1
- Status: Published application
- Kind: A1
- Application number: 12/078,985
- Filed: 2008-04-09
- Published: 2008-08-07
- Earliest claimed: 2004-03-08
- Inventors: Masao Hattori; Chia-Chin Sheu
- Web page: https://patentgrep.com/patent/US20080188669A1

## CPC

- C07D 207/46: with hetero atoms directly attached to the ring nitrogen atom
- C07D 207/444: having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D 307/60: Two oxygen atoms, e.g. succinic anhydride
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

The present invention relates to novel mixtures and maleic and succinic acid derivatives from mycelium of Antrodia camphorata and the medical use thereof. The present invention relates to the composition or mycelium comprising the compounds of the invention.

## Claims

### Claim at position 1

-14. (canceled)

### Claim 15

A compound having the formula
wherein
X is N or O;
R1 is C1-10 alkyloxy, C2-10 alkenyloxy, or C2-10 alkynyloxy;
R2 is H, C1-10 alkyl, C2-10 alkenyl or C2-10 alkynyl; and
R3 is absent, H or hydroxy;
provided that if X is O, R3 is absent.

### Claim 16 (depends on 15)

The compound of claim 15, wherein R1 is C2-6 alkenyloxy or C2-6 alkynyloxy.

### Claim 17 (depends on 16)

The compound of claim 16, wherein C2-6 alkenyloxy is substituted with C1-6 alkyl.

### Claim 18 (depends on 15)

The compound of claim 15, wherein R2 is isobutyl.

### Claim 19 (depends on 15)

The compound of claim 15, which is 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]furan-2,5-dione, 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrol-2,5-dione, 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrol-1-ol-2,5-dione, 3R*, 4S*-1-hydroxy-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dione, or 3R*, 4R*-1-hydroxy-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dione.

### Claim 20

A composition comprising a compound having the formula
wherein
X is N or O;
R1 is C1-10 alkyloxy, C2-10 alkenyloxy, or C2-10 alkynyloxy;
R2 is H, C1-10 alkyl, C2-10 alkenyl or C2-10 alkynyl; and
R3 is absent, H or hydroxy;
provided that if X is O, R3 is absent.

### Claim 21 (depends on 20)

The composition of claim 20, wherein the compound is 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]furan-2,5-dione, 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrol-2,5-dione, 3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]-1H-pyrrol-1-ol-2,5-dione, 3R*, 4S*-1-hydroxy-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dione, or 3R*, 4R*-1-hydroxy-3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]pyrrolidine-2,5-dione.

### Claim 22 (depends on 20)

The composition of claim 20, which decreases systolic blood pressure or increases high density lipoprotein.

### Claim 23 (depends on 20)

The composition of claim 20, which has central cholinergic agonism, hepatoprotection, anti-inflammation or anti-tumor activity.

### Claim 24 (depends on 20)

The composition of claim 20, wherein tumor is from the cells or tissues selected from the group consisting of liver, intestine, bone, blood, lymph and breast.