# US 2008/0188563 A1 · Blood fluidity improving agent

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- Number: US 2008/0188563 A1
- Document ID: US20080188563A1
- Status: Published application
- Kind: A1
- Application number: 12/059,547
- Filed: 2008-03-31
- Published: 2008-08-07
- Earliest claimed: 2002-11-06
- Assignees: Kao Corporation
- Inventors: Youichi Arai; Takuya Watanabe; Atsushi Suzuki; Hiroko Joukura
- Web page: https://patentgrep.com/patent/US20080188563A1

## CPC

- A61K 31/216: of acids having aromatic rings, e.g. benactizyne, clofibrate
- A23L 2/52: Adding ingredients (adding preservatives A23B70/10)
- A23L 33/10: using additives (addition of substantially indigestible substances A23L33/21)
- A61K 31/192: having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid {(cannabinoids A61K31/658)}
- A61P 7/00: Drugs for disorders of the blood or the extracellular fluid
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

A blood fluidity-improving agent, a blood circulation promoter or a cerebrovascular disease-improving agent, containing as an active ingredient thereof one or more ingredients selected from the group consisting of chlorogenic acids, caffeic acids, ferulic acids and pharmaceutically acceptable salts of these acids. The present blood fluidity-improving agent, blood circulation promoter or cerebrovascular disease-improving agent is highly safe and can be orally taken over longer periods of time.

## Claims

### Claim at position 1

1-16. (canceled)

### Claim 17

A method of improving the blood fluidity, comprising administering an effective dose of one or more ingredients selected from the group consisting of chlorogenic acids, caffeic acids, ferulic acids and pharmaceutically acceptable salts of these acids.

### Claim 18 (depends on 17)

The method of improving the blood fluidity according to claim 17, wherein said one or more ingredients selected from the group consisting of chlorogenic acids, caffeic acids, ferulic acids and pharmaceutically acceptable salts of these acids are administered in a daily dose ranging from about 10 mg to about 10 g.

### Claim at position 4

19-24. (canceled)

### Claim 25 (depends on 17)

The method of claim 17 wherein said active ingredient is chlorogenic acid and its pharmaceutically acceptable salts thereof.