# US 2008/0187932 A1 · Single Nucleotide Polymorphisms in Protein-Tyrosine Phosphatase Receptor-Type Delta for the Diagnosis of Susceptibility to Infection and Asthma

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 2008/0187932 A1
- Document ID: US20080187932A1
- Status: Published application
- Kind: A1
- Application number: 12/018,792
- Filed: 2008-01-23
- Published: 2008-08-07
- Earliest claimed: 2006-01-10
- Assignees: Vita Genomics, Inc.
- Inventors: Shih Hsin Wu; Ellson Ye-Shyon Chen
- Web page: https://patentgrep.com/patent/US20080187932A1

## CPC

- C12Q 1/6883: for diseases caused by alterations of genetic material
- G01N 33/5091: {for testing the pathological state of an organism}
- C12Q 2600/156: Polymorphic or mutational markers
- G01N 2800/122: Chronic or obstructive airway disorders, e.g. asthma COPD
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

A gene related to a susceptibility of infection and asthma—the Protein-Tyrosine Phosphatase Receptor-type Delta (PTPRD) gene—a method of detecting the asthma-associated gene, a method of predicting the occurrence of asthma, a method of identifying asthma-associated alleles in PTPRD gene, a method of screening PTPRD for drugs useful in the treatment of asthma, and antibodies specific for PTPRD variants and their use in diagnostic assays.

## Claims

### Claim 1

A method of determining susceptibility to asthma, said method comprising:
a) obtaining a biological sample from a patient;
b) detecting at least one allele within the Protein-Tyrosine Phosphatase Receptor-type Delta (PTPRD) gene;
c) determining if said allele is associated with asthma, thereby indicating that the patient is susceptible to asthma.

### Claim 2 (depends on 1)

The method of claim claim 1, wherein said allele is selected from the single nucleotide polymorphism (SNP) at rs2279776 or rs767674.

### Claim 3 (depends on 1)

The method of claim claim 1, wherein said SNP is an rs2279776 loci and said loci is a C allele.

### Claim 4 (depends on 1)

The method of claim claim 1, wherein said SNP is an rs767674 loci and said loci is a G allele.

### Claim 5 (depends on 1)

The method of claim claim 1, wherein said SNP is detected by genotyping.

### Claim 6 (depends on 5)

The method of claim claim 5, said genotyping includes TAQMAN®, MC-PCR, or SNAPSHOT™ analysis.

### Claim 7

A method of identifying alleles associated with susceptibility to asthma, said method comprising:
a) obtaining biological samples from a population of patients having asthma and a population of patients not having asthma;
b) identifying at least one allele in the PTPRD gene from each biological sample; and
c) showing an association between said allele and said patients having asthma, but not with said patients not having asthma; and
d) thereby identifying said allele as associated with susceptibility to asthma.

### Claim 8 (depends on 7)

The method of claim claim 7, wherein said allele is selected from an SNP comprising SEQ ID NO: 1-68.

### Claim 9 (depends on 7)

The method of claim claim 7, wherein said allele is a polymorphism of loci rs2279776 and rs767674.

### Claim 10 (depends on 8)

The method of claim claim 8, wherein the identifying step comprising genotyping.

### Claim 11 (depends on 10)

The method of claim claim 10, the genotyping includes TAQMAN®, MC-PCR, or SNAPSHOT™ analysis.

### Claim 12

A method of determining susceptibility to asthma, comprising obtaining a biological sample from a patient and detecting at least one allele within the PTPRD gene, wherein said allele is a C at the rs2279776 loci or a G at the rs767674 loci, thereby indicating that the patient is susceptible to asthma.

### Claim 13 (depends on 12)

The method of claim 12, wherein detecting both a C at the rs2279776 loci and a G at the rs767674 loci indicates that the patient has higher susceptible to asthma than if only a single allele is detected.

### Claim at position 14

14-16. (canceled)