# US 2008/0187920 A1 · Diagnostics and therapeutics for diseases associated with an il-1 inflammatory haplotype

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- Number: US 2008/0187920 A1
- Document ID: US20080187920A1
- Status: Published application
- Kind: A1
- Application number: 11/866,073
- Filed: 2007-10-02
- Published: 2008-08-07
- Earliest claimed: 1997-05-29
- Inventors: Gordon W. Duff; Angela Cox; Nicola Jane Camp; Francesco S. di Giovine
- Web page: https://patentgrep.com/patent/US20080187920A1

## CPC

- G01N 33/5008: {for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics}
- C12Q 1/6883: for diseases caused by alterations of genetic material
- G01N 33/502: {for testing non-proliferative effects}
- G01N 33/5091: {for testing the pathological state of an organism}
- C12Q 2600/156: Polymorphic or mutational markers
- C12Q 2600/172: Haplotypes
- Y10T 436/143333: Saccharide [e.g., DNA, etc.]
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- C12Q: MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS (immunoassay G01N33/53); COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

Methods and kits for determining whether a subject has or is predisposed to developing a disease which is associated with IL-1 polymorphisms and assays for identifying therapeutics for treating and/or preventing the development of these diseases are provided.

## Claims

### Claim 1

A kit comprising a means for detecting one or more alleles selected from the group consisting of: allele 2 of the −511 marker of IL-B, allele 2 of +2018 of IL-1RN, allele 1 of the −511 marker of IL-1B, and allele 1 of +2018 of IL-1RN.

### Claim 2

A kit comprising a means for detecting at least two alleles selected from the group consisting of: allele 2 of the −511 marker of IL-1B, allele 2 of +2018 of IL-1RN, allele 1 of the −511 marker of IL-1B, and allele 1of +2018 of IL-1RN.

### Claim 3 (depends on 1)

The kit of claim 1, wherein said detecting means is used in a allele detection technique selected from the group consisting of:
a) allele specific oligonucleotide hybridization;
b) size analysis;
c) sequencing;
d) hybridization;
e) 5′ nuclease digestion;
f) single-stranded conformation polymorphism;
g) allele specific hybridization;
h) primer specific extension; and
i) oligonucleotide ligation assay.

### Claim at position 4

4-22. (canceled)

### Claim 23 (depends on 2)

The kit of claim 2, wherein said detecting means is used in a allele detection technique selected from the group consisting of:
a) allele specific oligonucleotide hybridization;
b) size analysis;
c) sequencing;
d) hybridization;
e) 5′ nuclease digestion;
f) single-stranded conformation polymorphism;
g) allele specific hybridization;
h) primer specific extension; and
i) oligonucleotide ligation assay.

### Claim 24 (depends on 1)

The kit of claim 1, wherein the detection means comprise oligonucleotides.

### Claim 25 (depends on 24)

The kit of claim 24, wherein the oligonucleotides are selected from the group consisting of polymerase chain reaction (PCR) primers, cDNAs, peptide nucleic acids (PNAs), restriction fragments and synthetic oligonucleotides.

### Claim 26 (depends on 2)

The kit of claim 2, wherein the detection means comprise oligonucleotides.

### Claim 27 (depends on 26)

The kit of claim 26, wherein the oligonucleotides are selected from the group consisting of polymerase chain reaction (PCR) primers, cDNAs, peptide nucleic acids (PNAs), restriction fragments and synthetic oligonucleotides.