# US 2008/0187894 A1 · Method and System for Interactive Cognitive Testing

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- Number: US 2008/0187894 A1
- Document ID: US20080187894A1
- Status: Published application
- Kind: A1
- Application number: 11/956,580
- Filed: 2007-12-14
- Published: 2008-08-07
- Earliest claimed: 2006-12-14
- Inventors: Roger K. Cady
- Web page: https://patentgrep.com/patent/US20080187894A1

## CPC

- A61B 5/16: Devices for psychotechnics (using teaching or educational appliances G09B1/00 - G09B7/00); Testing reaction times {; Devices for evaluating the psychological state}
- A61B 5/165: {Evaluating the state of mind, e.g. depression, anxiety}
- G01N 33/5438: {Electrodes}
- A61B 5/0022: {Monitoring a patient using a global network, e.g. telephone networks, internet}
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

A cognitive testing and assessment system includes a testing module, said testing module having an input device, a memory, and at least one cognitive test battery stored in said memory, a wireless communication module, and an assessment and response module. The wireless communication module allows the system to communicate with external devices or networks, such as the Internet, local area networks, wide area networks, satellites, or cellular networks, without a wired connection. The assessment and response center may be either integrated into the system or located in a remote centralized or regional facility that the system accesses via the wireless communication module.

## Claims

### Claim 1

A wireless, interactive cognitive testing system, comprising:
a testing module, said testing module having an input device, a memory, and at least one cognitive test battery stored in said memory,
a wireless communication module, and
an assessment and response module.

### Claim 2 (depends on 1)

The wireless, interactive cognitive testing system of claim 1, further comprising a biometric testing module.

### Claim 3 (depends on 2)

The wireless, interactive cognitive testing system of claim 2, wherein said biometric testing module comprises:
a biosensor comprising a substrate having an electrical impedance and a coating;
at least a first antibody corresponding to at least a first biological marker on said coating, said antibody operative for binding with said biological marker present in a sample of saliva from a human patient; and
a microprocessor in communication with said biosensor, said microprocessor operable for accepting an electrical signal from said biosensor and producing test data corresponding to said electrical signal.

### Claim 4 (depends on 3)

The wireless, interactive cognitive testing system of claim 3, wherein said biological marker is selected from the group consisting of inflammatory peptides, proteins, human growth factors, endorphins, enkephalins, prostaglandins, and cytokines.

### Claim 5 (depends on 3)

The wireless, interactive cognitive testing system of claim 3, wherein said biological marker is selected from the group consisting of calcitonin-gene-related peptide, vasoactive intestinal peptide, neurokinin A and B, substance P, c-reactive protein, amylase, IgG, IgA, nitric oxide, prostaglandins, and histamine.

### Claim 6 (depends on 3)

The wireless, interactive cognitive testing system of claim 3, wherein said coating comprises D-poly lysine.

### Claim 7 (depends on 3)

The wireless, interactive cognitive testing system of claim 3, wherein said substrate comprises a gold ribbon.

### Claim 8 (depends on 1)

The wireless, interactive cognitive testing system of claim 1, wherein said cognitive test battery comprises at least one test from the Automated Neuropsychological Assessment Metrics (ANAM).

### Claim 9 (depends on 8)

The wireless, interactive cognitive testing system of claim 8, wherein said cognitive test battery consists of a Simple Reaction Time test, a Running Memory Continuous Performance test, a Matching to Sample test, and a Mathematical Processing test.

### Claim 10 (depends on 8)

The wireless, interactive cognitive testing system of claim 8, wherein said cognitive test battery consists of a Stanford Sleepiness Scale test and a Mood Scale 2 test, a Simple Reaction Time test, a Running Memory Continuous Performance test, a Matching to Sample test, and a Mathematical Processing test.

### Claim 11 (depends on 1)

The wireless, interactive cognitive testing system of claim 1, wherein said assessment and response module is housed with said testing module and said wireless communication module.

### Claim 12 (depends on 1)

The wireless, interactive cognitive testing system of claim 1, wherein said assessment and response module is located remotely from said testing module and said wireless communication module.

### Claim 13 (depends on 12)

The wireless interactive cognitive testing system of claim 12, wherein said assessment and response module comprises a centralized facility.

### Claim 14 (depends on 12)

The wireless, interactive cognitive testing system of claim 12, wherein said assessment and response module comprises multiple regional facilities.

### Claim 15 (depends on 12)

The wireless, interactive cognitive testing system of claim 12, wherein said assessment and response module comprises at least one computer server.

### Claim 16 (depends on 12)

The wireless, interactive cognitive testing system of claim 12, wherein said assessment and response module comprise at least one human operator.

### Claim 17 (depends on 1)

The wireless, interactive cognitive testing system of claim 1, wherein said wireless communication module comprises at least one of the group consisting of a cellular transmitter/receiver, a wi-fi transmitter/receiver, a wireless broadband modem, a Bluetooth®, transmitter/receiver, and an infrared transmitter/receiver.

### Claim 18 (depends on 1)

The wireless, interactive cognitive testing system of claim 1, wherein said wireless communication module comprises a satellite telephone.

### Claim 19 (depends on 1)

The wireless, interactive cognitive testing system of claim 1, further comprising a GPS module.

### Claim 20

A wireless, interactive cognitive testing system, comprising:
a testing module, said testing module having an input device, a memory, and at least one cognitive test battery stored in said memory;
a biometric testing module;
a wireless communication module; and
an assessment and response module.

### Claim 21

A wireless, interactive cognitive testing system, comprising:
a testing module, said testing module having an input device, a memory, and at least one cognitive test battery comprising at least one test from the Automated Neuropsychological Assessment Metrics (ANAM) stored in said memory;
a wireless communication module; and
an assessment and response module.

### Claim 22

A method of wireless, interactive cognitive testing in a human patient, comprising the steps of:
providing a testing module having an input device, a memory, and at least one cognitive test battery stored in said memory, and
conducting at least one cognitive test with said cognitive test battery to produce at least one test result; and
transmitting said test result via a wireless communication module to an assessment and response module.

### Claim 23 (depends on 22)

The method of wireless, interactive cognitive testing of claim 22, further comprising the steps of:
providing a biosensor comprising a substrate having an electrical impedance and a coating, at least a first antibody corresponding to a first biological marker being arranged on said coating;
applying a sample of saliva from said human patient to said biosensor;
measuring a change in said electrical impedance of said biosensor substrate resulting from binding of said antibody with said biological marker present in said saliva sample:
converting said change in said electrical impedance of said biosensor substrate into a transmittable electrical signal;
transmitting said electrical signal to a microprocessor in communication with said biosensor;
producing test data in said microprocessor corresponding to said electrical signal; and
transmitting said test data via said wireless communication module to said assessment and response module.
