# US 2008/0187102 A1 · Orthovoltage radiotherapy > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2008/0187102 A1 - Document ID: US20080187102A1 - Status: Published application - Kind: A1 - Application number: 12/026,507 - Filed: 2008-02-05 - Published: 2008-08-07 - Earliest claimed: 2006-10-16 - Assignees: Oraya Therapeutics, Inc. - Inventors: Michael Gertner - Web page: https://patentgrep.com/patent/US20080187102A1 ## CPC - A61N 5/1049: {for verifying the position of the patient with respect to the radiation beam} - A61B 6/506: {for diagnosis of nerves} - A61F 9/009: Auxiliary devices making contact with the eyeball and coupling in laser light, {e.g. goniolenses (apparatus for eye examination A61B3/0008)} - A61N 5/1017: {Treatment of the eye, e.g. for "macular degeneration"} - A61B 2017/306: {holding by means of suction} - A61N 5/103: {Treatment planning systems} - A61N 2005/105: {using a laser alignment system} - A61N 2005/1056: {by projecting a visible image of the treatment field} - A61N 2005/1091: {Kilovoltage or orthovoltage range photons} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) ## Abstract A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, the ocular structures are placed in a global coordinate system based on ocular imaging. In some embodiments, the ocular structures inside the global coordinate system lead to direction of an automated positioning system that is directed based on the ocular structures within the coordinate system. In some embodiments, the position of the ocular structure is tracked and related to the status of the radiosurgery system. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, the structure is an eye and the eye is tracked by the system. In some embodiments, the eye is held in place and in some embodiments, the eye is fixed by the patient. In some embodiments, a fiducial is placed on the eye to aid in positioning. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments. ## Claims ### Claim 1 A method, of treating a region of an eye of a patient, comprising: producing an x-ray beam with a width of from about 0.5 mm to about 6 mm and having a photon energy between about 40 keV and about 250 keV; directing the x-ray beam toward the eye region; and exposing the region to a dose of from about 1 Gy to about 40 Gy of x-ray radiation. ### Claim 2 (depends on 1) The method of claim 1, further comprising providing a model of the eye, the model comprising anatomic data obtained by an imaging apparatus, wherein at least one of a width of the x-ray beam, the photon energy of the x-ray beam, and a trajectory of the x-ray beam is determined based on the model of the eye. ### Claim 3 (depends on 1) The method of claim 1, wherein the exposing comprises exposing the region to from about 15 Gy to about 25 Gy of x-ray radiation. ### Claim 4 (depends on 1) The method of claim 1, wherein the region comprises a retina of the eye. ### Claim 5 (depends on 4) The method of claim 4, further comprising reducing neovascularization in the eye by exposing the retina to the x-ray radiation. ### Claim 6 (depends on 4) The method of claim 4, further comprising substantially preventing progression from Dry Age-related Macular Degeneration to neovascularization by exposing the retina to the x-ray radiation. ### Claim 7 (depends on 1) The method of claim 1, further comprising administering to the patient at least one of heating, cooling, a VEGF antagonist, a VEGF-receptor antagonist, an antibody directed to VEGF or a VEGF receptor, microwave energy, radiofrequency energy, a laser, a photodynamic agent, and a radiodynamic agent, and a therapeutic agent. ### Claim 8 (depends on 1) The method of claim 1, further comprising directing a first x-ray beam to pass through the sclera of the eye to the retina of the eye from a first position external to the eye, and directing a second x-ray beam to pass through the sclera to the retina from a second position external to the eye. ### Claim 9 (depends on 1) The method of claim 1, wherein the x-ray beam is directed through the pars plana of the eye. ### Claim 10 (depends on 1) The method of claim 1, wherein the x-ray beam is directed to the macula of the eye. ### Claim 11 (depends on 1) The method of claim 1, wherein the x-ray beam is directed through the sclera of the eye to the macula of the eye. ### Claim 12 (depends on 1) The method of claim 1, wherein the exposing comprises dividing the dose between two or more beams. ### Claim 13 (depends on 1) The method of claim 1, wherein the exposing comprises dividing the dose between two or more treatment sessions, each of said treatment sessions occurring at least one day apart. ### Claim 14 (depends on 1) The method of claim 1, further comprising determining a position of the eye relative to the x-ray beam during the exposing of the region to the x-ray radiation and ceasing or reducing the x-ray beam if the position of the eye exceeds a movement threshold. ### Claim 15 A method, of treating an eye during a treatment period, comprising directing a radiation beam from a source outside the eye to a target in or on the retina of the eye, such that a dose of radiation delivered during the treatment period to at least one of the optic nerve and the lens of the eye is no more than about 40 percent of a target dose of radiation delivered to the target. ### Claim 16 (depends on 15) The method of claim 15, wherein the radiation beam is directed to the target in or on the retina such that it passes substantially through the pars plana of the eye. ### Claim 17 (depends on 15) The method of claim 15, wherein the directing comprises collimating the radiation beam to a width of from about 0.5 mm to about 6 mm. ### Claim 18 A method, of treating an eye during a treatment period, comprising directing a radiation beam from a source outside an eye to a target in the eye, such that a dose of radiation emitted during the treatment period to eye tissue located about 6 mm from a center of the target is no more than about 40 percent of a target dose of radiation emitted to the target. ### Claim 19 A method, of treating inflammation in a patient's eye, comprising: based on data indicative of a location of a region of inflammation in an eye, directing at least one x-ray beam from a source outside the eye, through an anterior region of the eye, to the region of inflammation, such that a dose of radiation emitted during a treatment period to eye tissue greater than about 6 mm from a center of the region of inflammation is no more than about 40 percent of the dose of radiation emitted to the region of inflammation. ### Claim 20 (depends on 19) The method of claim 19, wherein said region comprises drusen. ### Claim 21 (depends on 19) The method of claim 19, wherein the anterior region of the eye comprises the sclera of the eye. ### Claim 22 (depends on 19) The method of claim 19, further comprising filtering the x-ray beam such that the x-ray beam comprises alternating regions of higher intensity and lower intensity. ### Claim 23 (depends on 19) The method of claim 19, further comprising collimating the x-ray beam such that the x-ray beam has a cross-sectional dimension smaller than about 1 mm. ### Claim 24 (depends on 19) The method of claim 19, further comprising collimating the x-ray beam such that the x-ray beam has a cross-sectional dimension of between about 1 mm and about 5 mm. ### Claim 25 (depends on 19) The method of claim 19, further comprising directing the at least one x-ray beam toward the eye at an angle with respect to a treatment axis that is determined using an eye-contacting device. ### Claim 26 (depends on 25) The method of claim 25, wherein said eye-contacting device communicates data, indicative of a position of the eye, to an emitter that emits the at least one x-ray beam. ### Claim 27 (depends on 19) The method of claim 19, further comprising directing the at least one x-ray beam toward the eye at an angle to a treatment axis that is determined using one of a reflection of light off the eye, a fundus image, an image of a pupil of the eye, and an image of a limbus of the eye.