# US 2008/0187101 A1 · Orthovoltage radiotherapy > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2008/0187101 A1 - Document ID: US20080187101A1 - Status: Published application - Kind: A1 - Application number: 12/023,968 - Filed: 2008-01-31 - Published: 2008-08-07 - Earliest claimed: 2006-10-16 - Assignees: Oraya Therapeutics, Inc. - Inventors: Michael Gertner - Web page: https://patentgrep.com/patent/US20080187101A1 ## CPC - A61N 5/1049: {for verifying the position of the patient with respect to the radiation beam} - A61B 6/506: {for diagnosis of nerves} - A61F 9/009: Auxiliary devices making contact with the eyeball and coupling in laser light, {e.g. goniolenses (apparatus for eye examination A61B3/0008)} - A61N 5/1017: {Treatment of the eye, e.g. for "macular degeneration"} - A61B 2017/306: {holding by means of suction} - A61N 5/103: {Treatment planning systems} - A61N 2005/105: {using a laser alignment system} - A61N 2005/1056: {by projecting a visible image of the treatment field} - A61N 2005/1091: {Kilovoltage or orthovoltage range photons} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C) ## Abstract A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, the ocular structures are placed in a global coordinate system based on ocular imaging. In some embodiments, the ocular structures inside the global coordinate system lead to direction of an automated positioning system that is directed based on the ocular structures within the coordinate system. In some embodiments, the position of the ocular structure is tracked and related to the status of the radiosurgery system. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, the structure is an eye and the eye is tracked by the system. In some embodiments, the eye is held in place and in some embodiments, the eye is fixed by the patient. In some embodiments, a fiducial is placed on the eye to aid in positioning. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments. ## Claims ### Claim 1 A system, for treating an eye with radiation, comprising: a radiation source that emits radiation; a collimator that collimates the emitted radiation into a beam; an alignment system that aligns the beam with an axis traversing the eye; a gating mechanism that reduces radiation emission from the radiation source when the beam is not aligned with the axis; and a communication link between the alignment system and the gating mechanism that communicates data, regarding alignment of the beam with the axis, from the alignment system to the gating mechanism. ### Claim 2 (depends on 1) The system of claim 1, wherein the alignment system comprises a light emitter that emits a light beam that is substantially aligned with a long axis of the collimator. ### Claim 3 (depends on 2) The system of claim 2, wherein the light emitter comprises a laser. ### Claim 4 (depends on 2) The system of claim 2, further comprising a sensor that detects a reflection of the light beam. ### Claim 5 (depends on 1) The system of claim 1, wherein said axis traversing the eye is different from an axis that the emitted radiation follows through the eye. ### Claim 6 (depends on 1) The system of claim 1, wherein said axis traversing the eye is substantially perpendicular to a center of the cornea. ### Claim 7 (depends on 1) The system of claim 1, further comprising an image detection system, in communication with the alignment system, that detects at least one of a fundus, a limbus, a cornea, and a reflection off a surface of the eye. ### Claim 8 (depends on 7) The system of claim 7, wherein, when the image detection system detects a threshold movement of the eye, the gating mechanism ceases or reduces radiation emission from the radiation source. ### Claim 9 A system, for delivery of an x-ray beam to an eye of a patient, comprising: at least one x-ray collimator that, in use, is positioned within about 15 cm of the retina of the eye and that collimates an x-ray beam that is directed at the eye; and a laser that emits a laser beam toward the eye, the laser beam being substantially aligned with a long axis of the collimator and providing an indication of a direction of the x-ray beam emitted through the collimator. ### Claim 10 (depends on 9) The system of claim 9, wherein the laser beam is directed such that the indication of a direction of the x-ray beam is provided on a surface of the eye. ### Claim 11 (depends on 9) The system of claim 9, further comprising an eye contact member that is configured to contact the eye and maintain the eye in a substantially fixed position during delivery of the x-ray beam to the eye. ### Claim 12 (depends on 11) The system of claim 11, wherein the laser beam is directed such that the indication of a direction of the x-ray beam is provided on a surface of the eye contact member. ### Claim 13 (depends on 11) The system of claim 11, wherein the eye contact member comprises a material that is reflective, at least in part, of light having a same wavelength as the laser beam. ### Claim 14 (depends on 9) The system of claim 9, further comprising a power supply adapted to deliver between about 10 mA and about 800 mA of current to an anode of an x-ray tube that delivers the x-ray beam. ### Claim 15 (depends on 14) The system of claim 14, wherein said anode is one of a stationary anode and a rotating anode. ### Claim 16 A radiotherapy system, for treating diseased eye tissue, comprising: a collimator that collimates a radiation beam, emitted from a radiation source, to a cross-sectional width of the radiation beam of no more than about 6 mm, the collimator defining a first axis that the radiation beam follows when the radiation beam is emitted toward an eye; and a first light guide that emits a light beam toward the eye along a second axis that is aligned with the first axis, the light beam providing an indication of the first axis. ### Claim 17 (depends on 16) The system of claim 16, wherein the first axis and the second axis are substantially collinear. ### Claim 18 (depends on 16) The system of claim 16, further comprising a second light guide that projects a beam along a third axis that substantially intersects the second axis. ### Claim 19 (depends on 16) The system of claim 16, wherein the first light guide comprises a laser. ### Claim 20 A method, of delivering radiation to an eye, comprising: providing an anterior-posterior axis of the eye; defining a treatment axis relative to the anterior-posterior axis of the eye; aligning a collimator at an angle relative to the treatment axis, the collimator being configured to collimate an x-ray beam that is emitted toward the eye; emitting the x-ray beam toward the eye through the collimator and at the angle relative to the treatment axis; and collimating the x-ray beam to a cross-sectional dimension of less than about 6 mm. ### Claim 21 (depends on 20) The method of claim 20, further comprising aligning the collimated x-ray beam with a projected spot on the sclera of the eye. ### Claim 22 (depends on 21) The method of claim 21, further comprising aligning said spot with the treatment axis. ### Claim 23 (depends on 20) The method of claim 20, further comprising ceasing emission of the x-ray beam if the collimator is detected not to be aligned at the angle relative to the treatment axis. ### Claim 24 (depends on 20) The method of claim 20, wherein said treatment axis comprises an optical central axis of the eye. ### Claim 25 (depends on 20) The method of claim 20, wherein said treatment axis comprises a visual axis of the eye. ### Claim 26 (depends on 20) The method of claim 20, further comprising moving the collimator relative to the treatment axis and emitting an additional collimated x-ray beam toward the eye. ### Claim 27 (depends on 20) The method of claim 20, further comprising moving the eye relative to the treatment axis. ### Claim 28 (depends on 20) The method of claim 20, wherein the collimating produces an x-ray beam that has a penumbra of less than about 2 mm at about 15 cm from the collimator. ### Claim 29 (depends on 20) The method of claim 20, wherein the collimating produces an x-ray beam that has a penumbra of less than about 2 mm at about 10 cm from the collimator.