Pacing output configuration selection for cardiac resynchronization therapy patients

A method, comprising:

• sensing, from within a patient, one or more cardiac electrical signals, including a cardiac electrical signal from at least one left ventricular electrode site;
• detecting a change in a timing interval between first and second cardiac electrical signal features associated with ventricular depolarization, the timing interval associated with a degree of responsiveness of the at least one left ventricular electrode site to cardiac resynchronization pacing therapy (CRT);
• and
• monitoring for a change in hemodynamic status of the patient based on the detected timing interval change.

A cardiac therapy system, comprising:

• multiple electrodes respectively positionable at multiple locations within at least a left ventricle for sensing cardiac electrical signals from a plurality of left ventricular electrode sites;
• a pulse generator coupled to the multiple electrodes and configured to deliver at least a cardiac resynchronization therapy (CRT);
• and
• a processor coupled to the multiple electrodes and the pulse generator, the processor configured to measure, for each left ventricular electrode site, a timing interval between first and second cardiac signal features associated with left ventricular depolarization, the timing interval associated with a degree of responsiveness of each left ventricular electrode site to CRT, the processor configured to determine a pacing output configuration that provides improved patient responsiveness to CRT based on the timing interval measurements and to select at least one left ventricular electrode site from the plurality of left ventricular electrode sites based on the timing interval measurements.

A cardiac therapy system, comprising:

• multiple electrodes respectively positionable at multiple locations within at least a left ventricle for sensing cardiac electrical signals from at least one left ventricular electrode site;
• a pulse generator coupled to the multiple electrodes and configured to deliver at least a cardiac resynchronization therapy (CRT);
• and
• a processor coupled to the multiple electrodes and the pulse generator, the processor configured to detect a change in a timing interval between first and second cardiac signal features associated with ventricular depolarization, the timing interval associated with a degree of responsiveness of the at least one left ventricular electrode site to CRT, the processor configured to monitor for a change in hemodynamic status of the patient based on the detected timing interval change.