Intranasal Cartridge Devices

A device for dispensing a predetermined quantity of fluid into the nasal passage of a user, said device comprising:

• a user operated trigger device;
• an actuator in contact with the trigger device;
• a plunger connected to the actuator;
• an dosage form containing the fluid;
• a piercing mechanism;
• a discharge nozzle;
• and
• a bite arm positioned to control the direction of the discharge into the nasal passage of a user during use;
• wherein operating the trigger causes the piercing mechanism to penetrate the dosage form and discharge the fluid through the discharge channel;
• and further wherein the actuator provides a mechanical advantage or a mechanical disadvantage to the discharge process.

A device for dispensing a predetermined quantity of fluid into the nasal passage of a user, said device comprising:

• a body;
• a user operated trigger device;
• an actuator in contact with the trigger device;
• a plunger connected to the actuator;
• an dosage form comprising a piercable membrane and containing the fluid;
• and
• a piercing mechanism;
• wherein operating the trigger causes the piercing mechanism to penetrate the dosage form and discharge the fluid through the discharge channel;
• and further wherein the actuator provides a mechanical advantage or a mechanical disadvantage to the discharge process.

A device for dispensing a predetermined quantity of fluid into the nasal passage of a user, said device comprising:

• a body;
• a user operated trigger device;
• an actuator in contact with the trigger device;
• a plunger connected to the actuator;
• and
• a removable tip comprising:
• a discharge nozzle;
• one or more dosage forms comprising a piercable membrane, wherein the one or more dosage forms contain a piercing mechanism and a predetermined quantity of fluid;
• wherein the tip fits onto the body to place at least one dosage form adjacent the plunger;
• wherein operating the trigger causes the piercing mechanism to penetrate the dosage form and discharge the fluid through the discharge nozzle;
• and further wherein the actuator provides a mechanical advantage or a mechanical disadvantage to the discharge process.

A device for dispensing a predetermined quantity of fluid in two separate discharges into nasal passages of a user, said device comprising:

• a body;
• a user operated trigger device;
• an actuator in contact with the trigger device;
• a discharge nozzle;
• a plunger connected to the actuator wherein operating the trigger causes the plunger to crush the dosage form against the piercing mechanism to penetrate the dosage form and discharge the fluid through the discharge nozzle;
• and
• a cylinder containing the plunger and providing a path for the plunger to contact and crush the dosage form;
• wherein the discharge nozzle is rotatable from at least a first position to a second position, such that when the discharge nozzle is in the first position, a stop is positioned in the cylinder so that when the trigger is operated during use, the plunger is stopped after partial emptying of the dosage form, and when the discharge nozzle is in the second position, the stop is moved to allow the plunger to discharge substantially the entire contents of the dosage form when the trigger is operated during use;
• and further wherein the actuator provides a mechanical advantage to the discharge process.

A piercing nozzle for dispensing fluid from an dosage form in a controlled spray pattern and droplet size, the nozzle comprising a substantially elongate member with an inlet end and a discharge end, comprising:

• an internal channel connecting the inlet end and the discharge end in fluid communication;
• one or more inlet openings in the inlet end;
• a discharge opening in the discharge end, and;
• features on the internal channel surface to control the spray pattern and droplet size of a fluid forced through the nozzle.

An internally pierced dosage form comprising:

• a substantially dome shaped, flexible blister;
• a substantially round pierceable surface sealed to the base of the dome-shaped blister;
• and
• an internal chamber;
• wherein the internal chamber contains a piercing nozzle and a medical composition;
• and wherein the piercing nozzle comprises:
• an internal channel comprising features on the internal surface to control the spray pattern and droplet size of a fluid forced to flow through the nozzle;
• one or more inlet openings providing a fluid path from the internal chamber of the dome shaped blister into the internal channel of the piercing nozzle;
• and
• a discharge opening, wherein the internal channel provides fluid communication from the one or more inlet openings to the discharge opening;
• wherein the fluid path comprises one or more bends as the fluid flows into the internal channel from the internal chamber.

A dosage form for administration in a liquid spray, comprising:

• a blister and a backing, wherein the blister is divided into a first blister chamber and one or more second blister chambers, each separated from the first blister chamber by a secondary seal;
• and
• a primary seal, wherein the second seal seals the circumference of the blister to the backing;
• and
• a first liquid or powder composition within the first blister chamber and a second liquid or powder composition within at least one second blister chamber, wherein at least one of the compositions is a liquid;
• wherein a secondary seal has less adhesion than the primary seal such that when a sufficient pressure is applied to a chamber, a secondary seal will release, allowing the contents of the pressurized chamber to flow into an adjoining chamber, mixing the contents of the adjoining chambers while the primary seal remains intact.

A method for dispensing a pharmaceutical composition comprising two components, wherein the two components are mixed immediately prior to dispensing, the method comprising:

• providing a multi chambered dosage form wherein a first component is contained in a first, crushable chamber and a second component is contained in a second, expandable chamber containing an internal piercing mechanism and discharge outlet, wherein the first and second chamber are separated by an adhesive seal;
• providing a mechanical pressure to crush the crushable chamber, breaking the adhesive seal and forcing the contents of the crushable chamber into the expandable chamber;
• and providing a second mechanical pressure to the expandable chamber to pierce the expandable chamber with the piercing mechanism and force the contents of the expandable chamber through the piercing mechanism and out the discharge outlet;
• wherein at least one of the components is a liquid.