Taurolidine Formulations and Delivery: Therapeutic Treatments and Antimicrobial Protection Against Bacterial Biofilm Formation
OwnerHans-Dietrich Polaschegginventor
Life of this patent
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Abstract
Treating of localized bacterial infection, comprising locally applying Taurolidine to the infection. A device for insertion into the body, the device comprising Taurolidine to render the device infection resistant. A medication for treating bacterial infections, comprising Taurolidine carried by one of: gels, liquid, thixotropic gels, colloidal mixtures, dispensal suspensions, injectable polymers, or a microparticle. A method for treating blood, comprising: removing blood from the body; treating the blood with Taurolidine; and returning the treated blood.
Claims47
A method for treating a localized bacterial infection, comprising locally applying Taurolidine to the bacterial infection.
A device for treating a localized bacterial infection, wherein the device carries Taurolidine therewith.
A device for insertion into the body, the device comprising Taurolidine, whereby to render the device infection resistant.
A method for treating a lung infection, comprising inhaling a Taurolidine-carrying aerosol.
A method for treating a lung infection, comprising inhaling Taurolidine particles.
A medication for treating bacterial infections, comprising Taurolidine carried by one from the group consisting of:
- gels, liquids, thixotropic gels, colloidal mixtures, dispersal suspensions, and injectable polymers, the medication having a Taurolidine concentration sufficiently high, and capable of being applied to a specific region for a sufficient period of time, to treat the infection.
A medication for treating bacterial infections, comprising Taurolidine carried by a microparticle, wherein the microparticle comprises one from the group consisting of:
- Resomer bioerodible plastics, Resomer bioerodible gels, microspheres, protein solid microspheres, colloidal materials, liposomes and composite silicone/hydrogel materials.
A method for using a reusable medical device, comprising positioning the reusable medical devices in a Taurolidine solution before use.
A composition comprising Taurolidine and various pluronic formulations.
A composition comprising Taurolidine and Hyaluronic acid (HA) and water.
A composition comprising Taurolidine and chitin and water.
A composition comprising Taurolidine, and chitosan or alginate, and water.
A composition comprising Taurolidine and cyclodextrin and water.
A composition comprising polyethylene glycol (PEG) based hydrogel system.
A composition comprising Taurolidine, wherein the composition is injectable and comprises a scaffold upon subcutaneous administration so as to provide a filler for a body cavity or act as a compliant implant and release the Taurolidine in vivo.
An endotracheal tube comprising:
- a tube;
- an inflatable collar attached to the outer wall of the tube, the inflatable collar comprising a material permeable to Taurolidine;
- and
- a passageway extending along the tube and connected to the inflatable collar;
- whereby Taurolidine may be introduced to the inflatable collar from outside the body in a flow and pressure controlled manner so as to inflate the collar and deliver Taurolidine around the periphery of the collar and/or the tube outer surface distal to the collar.
A method for ventilating a patient, comprising:
- providing an endotracheal tube comprising:
- a tube;
- an inflatable collar attached to the outer wall of the tube, the outer inflatable collar comprising a material permeable to Taurolidine;
- and
- a passageway extending along said tube and connected to the inflatable collar;
- positioning the tube in the trachea;
- introducing Taurolidine into the inflatable collar from outside the body in a flow and pressure controlled manner so as to inflate the collar and deliver Taurolidine around the periphery of the collar and/or the tube outer surface distal to the collar;
- and
- ventilating the patient.
A urinary catheter comprising:
- a tube;
- an inflatable collar attached to the outer wall of the tube, the outer inflatable collar comprising a material permeable to Taurolidine;
- and
- a passageway extending along said tube and connected to the inflatable collar;
- whereby Taurolidine may be introduced to the inflatable collar from outside the body in a flow and pressure controlled manner so as to inflate the collar and deliver Taurolidine around the periphery of the collar and/or the catheter outer surface distal to the collar.
A method for treating a patient, comprising:
- providing a urinary catheter comprising:
- a tube;
- an inflatable collar attached to the outer wall of the tube, the outer inflatable collar comprising a material permeable to Taurolidine;
- and
- a passageway extending along said tube and connected to the inflatable collar;
- whereby Taurolidine may be introduced to the inflatable collar so as to inflate the collar and deploy Taurolidine around the periphery of the collar;
- positioning the tube in the urethra;
- introducing Taurolidine into the inflatable collar from outside the body in a flow and pressure controlled manner so as to inflate the collar and deliver Taurolidine around the periphery of the collar and/or the catheter outer surface distal to the collar.
A Taurolidine depot adapted to be deposited within the body during a medical procedure, and thereafter deliver Taurolidine to the tissue adjacent to the body.
A method for treating a patient, comprising:
- providing a Taurolidine depot adapted to be deposited within the body during a medical procedure, and thereafter deliver Taurolidine to the tissue adjacent to the body;
- and
- depositing the Taurolidine depot within the body during a medical procedure.
A method for treating blood, comprising:
- removing blood from the body;
- treating the removed blood with Taurolidine;
- and
- returning the treated blood to the body.
Apparatus for treating blood, comprising:
- removal apparatus for removing blood from the body;
- treatment apparatus for treating the removed blood with Taurolidine;
- and
- return apparatus for returning the treated blood to the body.
Dependencies are inferred from the claim text.