Therapeutic agent delivery systems and devices
AssigneeThe Regents of the University of California
InventorsMark Bachman, Baruch Kupperman, Asheesh Divetia, Guann Pyng Li
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Abstract
Devices, systems and methods for delivering pre-determined quantities of an active ingredient to a biological system are provided.
Claims22
A device for controlled release of an active ingredient, the device comprising:
- a) a release aperture operably associated with a deflectable member;
- b) a base comprising a porous substrate layer;
- and
- c) at lease one chamber juxtaposed between the release aperture and the porous substrate layer, the chamber containing a matrix comprising one or more active ingredients and an agent that expands when contacted with an aqueous solution,
- wherein the device is suitable for implantation in a biological system.
A device for controlled release of an active ingredient, the device comprising:
- a) a release aperture operably associated with a deflectable member;
- b) a base comprising a porous substrate layer;
- and
- c) at lease one chamber juxtaposed between the release aperture and the porous substrate layer, the chamber comprising:
- i) a first compartment comprising an active ingredient;
- and
- ii) a second compartment comprising an agent that expands when contacted with an aqueous solution,
- wherein the device is suitable for implantation in a biological system.
A device for controlled release of an active ingredient, the device comprising:
- a) a plurality of chambers, each chamber comprising a release aperture operably associated with a deflectable member and an active ingredient;
- b) a compartment comprising an agent that expands when contacted with an aqueous solution, wherein the compartment is in expandable communication with each chamber of the device;
- and
- c) a base comprising a porous substrate layer adjacent to and in fluidic communication with the compartment,
- wherein the device is suitable for implantation in a biological system.
A computer-assisted method for designing a device or system for controlled release of an active ingredient in a biological system, the method comprising:
- a) selecting at least one active ingredient for controlled release in a biological system;
- b) identifying a dosing profile suitable for eliciting an active ingredient-induced response in the biological system;
- c) determining the geometries of the device or system suitable to obtain the dosing profile of b) using finite element analysis;
- d) optionally repeat b) and c);
- and
- e) manufacturing the device or system according to the identified geometry.
A device for controlled release of an active ingredient and suitable for implantation in a biological system, the device comprising:
- a) a first non-porous plate;
- b) a second non-porous plate;
- and
- c) a matrix juxtaposed between the first and second plate, the matrix comprising:
- i) a first porous material comprising one or more active ingredients positioned in a pre-determined pattern;
- and
- ii) a second porous material encapsulating the first porous material and in fluid communication with the biological system in which the device is implanted.
Dependencies are inferred from the claim text.