Method of Synthesizing Compound
AssigneesDaihatsu Motor Co., Ltd., Hokko Chemical Industry Co., Ltd.
InventorsHirohisa Tanaka, Kimiyoshi Kaneko
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Abstract
In order to provide a method of synthesizing a compound in which activity of a catalyst is maintained even when the catalyst is recovered after the completion of the coupling reaction using a palladium-containing perovskite-type composite oxide as the catalyst and used repeatedly and the reaction can be carried out in a high yield, a palladium-containing perovskite-type composite oxide is used as a synthesis reaction catalyst and a reaction solvent containing an alkoxy alcohol is used as a reaction solvent in Suzuki Cross-Couplings given by the following general formula (15).
Claims4
A method of synthesizing a compound, which comprises reacting a compound represented by the following general formula (1) with a compound represented by the following general formula (2) or a compound represented by the following general formula (3) in the presence of a palladium-containing perovskite-type composite oxide using a reaction solvent containing an alkoxy alcohol:
- R1—X (1)
- wherein R1 represents an aryl group which may have a substituent, a heterocyclic group which may have a substituent, or an alkenyl group which may have a substituent;
- and X represents a halogen atom, a trifluoromethanesulfonyloxy group, a p-toluenesulfonyloxy group or a methanesulfonyloxy group,
- R2-M (2)
- wherein R2 represents an aryl group which may have a substituent, a heterocyclic group which may have a substituent, or an alkenyl group which may have a substituent;
- M represents a —B(ORa)2— group or a —Sn(Rb)3 group;
- Ra represents a hydrogen atom or an alkyl group which may have a substituent;
- and Rb represents an alkyl group, and instead of Ra, a ring including —OBO— may be formed through an arylene group which may have a substituent or an alkylene group which may have a substituent, both of which serve as a bond of —OBO—, and
- R3HC═CR4R5 (3)
- wherein R3, R4 and R5 each independently represents a hydrogen atom, an alkyl group which may have a substituent, an aryl group which may have a substituent, a carboxylic acid derivative, an acid amide derivative or a cyano group.
Dependencies are inferred from the claim text.