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US 2008/0177069 A1Published application
Process for producing 4-aminoquinazoline compound
AssigneeUbe Industries, Ltd.
InventorsShigeyoshi NISHINO, Kenji HIROTSU, Hidetaka SHIMA, Takashi HARADA, Hiroyuki ODA
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Abstract
A 4-aminoquinazoline derivative can be obtained by the steps of reacting quinazolin-4-one or its derivative with a chlorinating agent in a first organic solvent in the presence of an organic base, and subsequently reacting the reaction product with an amine compound represented by the formula R5—NH—R6 (each of R5 and R6 represents hydrogen or an optionally substituted hydrocarbyl group) in the presence of a second organic solvent.
Claims1
A process for preparing a 4-aminoquinazoline compound having the formula (3):
- in which each of R1, R2, R3 and R4 independently represents a group not participating the below-mentioned reaction, or R1, R2, R3 and R4 are combined to form a ring, and each of R5 and R6 independently represents a hydrogen atom or a hydrocarbyl group which can have a
- which comprises:
- a first step of reacting a quinazolin-4-one compound having the formula (1):
- in which R1, R2, R3 and R4 have the same meaning as above,
- with a chlorinating agent in a first organic solvent in the presence of an organic base and
- a second step for reacting a reaction product of the first step with an amine compound having the formula (2):
- R5—NH—R6 (2)
- in which R5 and R6 have the same meaning as above,
- in the presence of a second organic solvent.
6 more elements
Dependencies are inferred from the claim text.