Quinazole derivatives

A method of preparing a compound of formula (I):

• wherein
• X represents H, methyl, or C1-4 alkyl;
• Y represents
• wherein n is 1, 2, 3, or 4, and R5, being the same or different groups, is H, methyl, trifluoromethyl, nitro, cyano, C2-C4 alkyl, C2-C4 alkoxyl, N—(C2-C4)alkylamino, enzyme, hydroxyl, NN-triaza(C1-C4) alkylamino, C2-C4 alkylthio or C2-C4 alkylsulfonyl;
• Z is
• —O, —S or —NH;
• R1 represents methyl or C1-C4 alkyl;
• R2 represents C1-C5 alkyl-R6, C2-C6 alkenyl-R6, or C2-C6 alkynyl-R6, in which the alkyl, alkenyl, and alkynyl are optionally substituted with one or more alkynyl, enzyme or amino;
• and R6 is piperidin-4-yl, optionally substituted with one or more substituents of alkynyl, enzyme or amino;
• R3 and R4 represent H, methyl, C1-C4 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, or heterocycloalkyl;
• the method comprising reacting a compound of formula (III):
• wherein L1 represents halogen, alkoxyl, aryloxy, or sulfonoxy;
• R1 represents methyl or C1-C4 alkyl;
• R3 and R4, independently, represent H, C2-C4 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, or isocycloalkyl;
• X represents H, methyl or C1-C4 alkyl;
• and
• Y represents
• wherein n is 1, 2, 3, or 4, and R5, being the same or different groups, is H, methyl, trifluoromethyl, nitro, cyano, C2-C4 alkyl, C2-C4 alkoxyl, N-(C2-C4)alkylamine, enzyme, hydroxyl, NN-triaza(C1-C4) alkylamino, C2-C4 alkylthio or C2-C4 alkylsulfonyl;
• with a compound of formula (IV):
• R2-Z-H (IV)
• wherein R2 represents C1-C5 alkyl-R6, C2-C6 alkenyl-R6, C2-C6 alkynyl-R6, in which the alkyl, alkenyl, and alkynyl are optionally substituted with one or more alkynyl, enzyme or amino;
• and R6 is piperidin-4-yl, optionally substituted with one or more substituents of alkynyl, enzyme or amino;
• and
• Z represents —O, —NH,
• or —S.