Single-chain Antibodies Against Human Insulin-Like Growth Factor I Receptor: Expression, Purification, and Effect on Tumor Growth
AssigneeCity of Hope
InventorYoko Fujita-Yamaguchi
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Abstract
A method of inhibiting the growth of hormone dependent tumor cells in a mammal comprises administering to said mammal an insulin-like growth factor receptor (IGF-IR) recombinant antibody, wherein said antibody can be a single-chain recombinant antibody, which can be humanized, capable of blocking agonist interaction with the IGF-IR.
Claims3
A purified recombinant antibody comprising antigen binding portions having the binding specificity of the antigen binding portions of murine antibody 1H7.
A purified recombinant antibody comprising antigen binding portions of a VL domain and a VH domain comprising amino acid sequences as set forth in SEQ ID NO:6, SEQ ID NO:7, and SEQ ID NO:8, and in SEQ ID NO:9, SEQ ID NO:10, and SEQ ID NO:11, respectively.
Dependencies are inferred from the claim text.