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US 2008/0177045 A1Published application
Monoclonal antibodies against ANGPTL3
AssigneeLexicon Pharmaceuticals, Inc.
InventorsE-Chiang Lee, Gregory Landes, Seokjoo Hong, Urvi Desai, David Powell
Life of this patent
Estimating the term…
Abstract
Monoclonal antibodies that specifically bind to ANGPTL3 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL3 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided.
Claims26
A monoclonal antibody that binds to ANGPTL3 and neutralizes at least one activity of ANGPTL3.
-64. (canceled)
A monoclonal antibody that binds to ANGPTL3 and neutralizes at least one activity of ANGPTL3, wherein the antibody binds to a peptide having the amino acid sequence of SEQ ID NO:
- 9 with a KD of less than 50 nM.
-77. (canceled)
Dependencies are inferred from the claim text.