Selective Linear Peptides with Melanocortin-4 Receptor (MC4-R) Agonist Activity

A compound of the formula:

• wherein
• m is 0 or 1;
• n is 0 or 1;
• R1 is an unsubstituted linear or branched alkyl having from 1 to 8 carbon atoms;
• linear or branched alkyl having from 1 to 8 carbon atoms mono-substituted by phenyl or carboxyl;
• unsubstituted phenyl;
• or phenyl mono-substituted by fluoro, chloro or linear or branched alkyl having from 1 to 4 carbon atoms;
• X is
• wherein R2, R3 and R4 are independently hydrogen or a linear or branched alkoxy having from 1 to 4 carbon atoms, wherein when R3 is alkoxy, R2 and R4 are both hydrogen;
• R9 is hydrogen, linear or branched alkyl having from 1 to 3 carbons, linear or branched alkoxy having from 1 to 3 carbons, or unsubstituted phenoxy;
• R11 is cyclohexyl, cycloheptyl, or a branched alkyl having from 3 to 8 carbon atoms;
• R6 is hydrogen or methyl;
• R7 is
• and R8 is hydrogen or methyl;
• or
• Y is
• and R8 is hydrogen.