Taspase1 and Methods of Use
AssigneeDana-Farber Cancer Institute, Inc.
InventorsJames J.D. Hsieh, Stanley J. Korsmeyer, Susan Korsmeyer, Emily H. Y. Cheng
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Abstract
A novel protease, Taspase1, is described. Taspase1 is involved in the cleavage of the myeloid/lymphoid or mixed-lineage leukemia (i.e., MLL) protein, which is required for proper HOX gene regulation. Diagnostic methods utilizing Taspase1 are provided, as well as inhibitors of Taspase1. Methods of using the inhibitors of Taspase1 are also described. For example an inhibitor of Taspase1 can be used to treat a cancer, e.g., leukemia, in a subject.
Claims12
1-42. (canceled)
An inhibitor of a polypeptide comprising an amino acid sequence which is at least about 80% identical to the amino acid sequence of SEQ ID NO:1.
Dependencies are inferred from the claim text.